69 results
Primary objective: - 50% seizure reduction or more at 3 months of dietary treatment .Secondary objectives: -level of ketosis on KD and MAD.-number of patients maintaining >50% seizure reduction on MAD.-number of withdrawals (not able to…
Primary objective:To determine the response to a 144-hour (6 day) continuous intravenous infusion of SAGE-547 compared to placebo administered to support the weaning of all third-line agents in subjects with SRSE, and for the response to endure at…
The overall aim of this project is to elucidate the interaction between stress and epileptic seizures in childhood epilepsy. The specific aim of this study is to compare the possible differences in stress hormone regulation, hippocampal function and…
To assess the efficacy of GWP42003-P as an adjunctive antiepileptic treatment compared with placebo, with respect to the percentage change from baseline during the treatment period of the study in convulsive seizure frequency. The dose response…
Primary Objective: To assess whether early postoperative AED withdrawal improves cognitive function compared to late withdrawal.Secondary objectives: * To confirm safety of earlier AED withdrawal; we will assess eventual seizure freedom, seizure…
To assess the efficacy as well as the safety and tolerability of an investigational drug called UCB0942 that will be given in addition to the current epilepsy treatment of the patient.
Primary Objective: To determine whether GWP42003-P affects the pharmacokinetic (PK) profile of stiripentol (STP) or valproate (VPA).Secondary Objective: To assess the safety and tolerability of GWP42003-P in the presence of STP or VPA.To assess…
A primary goal is to relate EEG based rsFC to changes in excitability of the brain. Since the excitability recorded with the MEPs reflect antiepileptic drug effects [1,2] it is assumed that these changes will be more pronounced after withdrawal of…
The primary objective of this investigation is to assess the performance of the ANSeR Software System by quantifying and comparing the diagnostic accuracy of investigation personnel using the ANSeR Software System with the diagnostic accuracy of…
To assess the provoking effect of partial sleep deprivation on paroxysmal neurological events in a EMU setting, in people with possible epileptic seizures.
The main objective is to evaluate the effect of the modified Atkins diet on the seizure frequency of institutionalized adults with refractory epilepsy and severe intellectual disability.
Primary: To compare the reduction in frequency of partial-onset seizures on each of two trough ranges of everolimus (3-7 ng/mL and 9-15 ng/mL) versus placebo in patients with TSC who are taking one to three AEDs. Key secondary: Ability to completely…
The primary objective of this study is to evaluate the efficacy of 2 dose levels of pregabalin (Level 1: 2.5 mg/kg/day; maximum 150 mg day and Level 2: 10 mg/kg/day; maximum 600 mg day) compared to placebo as an adjunctive treatment in reducing the…
The objectives of this multi-centre, double-blind, randomized, 2-parallelgroups study are to investigate the efficacy, safety and tolerability of levetiracetam (LEV) monotherapy 15-60mg/kg/day versus valproic acid (VPA) monotherapy 10-40mg/kg/day in…
The primary objective of the clinical part of EPISTOP project is to identify the clinical and molecular biomarkers of epileptogenesis in a prospective clinical study of patients with TSC. Secondary objective of the clinical part of EPISTOP is to…
To compare the neurotransmitter networks of patients with localisation-related epilepsy patients to those of healthy subjects; To explore the relationship between neurotransmitter, functional and structural network properties, and relate these to…
Identification of a diseased neuronal network characteristic in children with nocturnal epileptiform activity, which can explain language impairment in these children
In this research, a small group of children known to suffer from complex febrile seizures (FS) will be studied. An increase in expression of FS1 will be investigated in blood in comparison with an control group. This will be done by isolating FS1…
Primary objective: To set up a repository of genetic material from a large group of well phenotyped people with epilepsy patients to allow the case control association studies, to analyze and detect genetic risk factors for epilepsy. Secondary…
Primary Objective: To demonstrate the cost-effectiveness of treatment with a ketogenic diet compared to usual care in children with drug-resistant epilepsy who are not eligible for epilepsy surgery. Usual care is defined as: the child continuous to…