127 results
The primary objective of this secondary prevention study is to evaluate the efficacy, safety, pharmacodynamics, and pharmacokinetics of gantenerumab, an anti-amyloid antibody, in amyloid-positive, cognitively unimpaired participants at risk for or…
Primary Objective:To investigate the effect of respiratory and physical exercises in VR on pulmonary recovery compared to the standard of care of patients suffering from blunt chest trauma.Secondary Objective(s):- To investigate if VRx can improve…
1. To evaluate the efficacy of a gait training program using an instrumented treadmill with virtual and augmented reality for improving gait adaptability in people in the chronic phase after stroke in an RCT. 2. To identify patient characteristics…
To assess the effectiveness and cost-effectiveness of providing an online personalized self-management program as a first-lineintervention to men with lower urinary tract symptoms (LUTS) compared to care as usual (CAU).
Primary Objective: - To determine and compare physical performance in patients with HNC with and without an exercise intervention.Secondary Objective(s): - To determine and compare muscle strength in patients with HNC with and without an exercise…
Sub-study APhase 1b:To assess the DLT rate and estimate the MTD of sasanlimab in combination with encorafenib and binimetinib to determine the RP2D for the combination. Phase 2:To assess the durable ORR of sasanlimab in combination with encorafenib…
Primary Objective: 1. To determine the effectiveness of a personalised, holistic 24-week digital lifestyle programme in achieving diabetes type 2 (T2DM) remission independence from blood glucose-lowering medications, in a Dutch population, in…
The following questions will be addressed in the PARASOL study• Is the proposed study design feasible?,We will set up the study as a randomized pilot study to evaluate if patients are willing and able to participate in a randomized trial, i.e. are…
Primary Objective: - To investigate the effectiveness of the ProMIO lifestyle intervention (targeting protein intake and exercise behavior) on physical functioning in older adults from ethnic minorities (Turkish, Moroccan and Surinamese). Secondary…
To study the impact of AKCEA-APOCIII-LRx on lipid and inflammatory measurements in the fasting and postprandial phase.
The main objective is to identify the optimal management for patients with an asymptomatic CPAM, based on functional outcome measures. Furthermore, the primary objective is to stratify asymptomatic CPAM patients into a low and high risk group for…
The primary objective of the trial is:To assess whether a non-surgical, fractional flow reserve (FFR) and optical coherence tomography (OCT)-guided treatment strategy* has a comparable outcome (MACE) with surgical revascularization of significant…
The aim of this exploratory study is to compare the effect of a lifestyle intervention program consisting of combined individual coaching and group sessions (CLI) with a lifestyle intervention program with individual coaching only (II).The program…
To investigate the effect of adding PIFM strengthening exercises to a functional exercise program compared to a functional exercise program alone on maximum gait speed in mobile older adults. The secondary objective is to also investigate the effect…
Primary objective - to describe immunogenicity and safety in healthy volunteers of the intradermal dermal delivery of a single fractional dose of 20µg mRNA-1273 LNP vaccine (Spikevax, Moderna) more than 3 months after primary vaccination with…
Part 1 - To determine the efficacy of oral BCX9930 monotherapy administered for 24 weeks, compared to continued complement component 5 (C5) inhibitor therapy, in subjects with paroxysmal nocturnal hemoglobinuria (PNH) with an inadequate response to…
Primary:• To evaluate the efficacy of PTC923 in reducing blood phenylalanine (Phe) levels in subjects with phenylketonuria (PKU) as measured by mean change in blood Phe levels from baseline to Weeks 5 and 6 (ie, the average of each respective…
To assess the impact of the combined ingestion of whey and collagen protein on myofibrillar and connective tissue protein synthesis rates in muscle tissue obtained at rest and during recovery from exercise in vivo in humans.
The purpose of the study is to evaluate how effective rilzabrutinib is and how safe it is, in reducing the signs and symptoms in patients with chronic spontaneous urticaria (CSU), who continue to have symptoms despite the use of H1-antihistamines (…
Primary• To evaluate the effect of EDP1815 (same dose using EC1 and EC2 capsules) and EDP2939 (two dose levels using EC2 capsules) on the immune system.Secondary• To evaluate the effect of EDP1815 (same dose using EC1 and EC2 capsules) and EDP2939 (…