Search for a trial

STEPWISE Parkinson: A smartphone based, titrated exercise solution for patients with Parkinson*s disease in daily life

The aim of this study is to investigate whether a smartphone app can increase physical activity in PDpatients for a long period of time (one year). The secondary aim is to test the potential effects of an increase in physical activity on physical…

Safety and preliminary protective efficacy of genetically attenuated Pf*mei2 (GA2) malaria parasites in healthy Dutch volunteers

Phase 1 • Primary objective: to determine the safety and tolerability, including the attenuation phenotype of a novel late-arresting GAP, named GA2 parasite, administered by sequentially increasing numbers of mosquito bites.• Secondary objective: to…

Internet-based emotion regulation training in adolescents with depressive and anxiety disorders: a randomized controlled trial.

The primary aim of the proposed study is to test the effectiveness of CBT + ERT in reducing depressive and anxiety symptoms against CBT alone in adolescent patients (aged 13-19) with depressive or anxiety disorders in a randomized controlled trial (…

An Open-Label, Randomised, Phase 4 Study of Continuing Sodium Zirconium Cyclosilicate (SZC) after Discharge in Participants with Chronic Kidney Disease treated for Hyperkalaemia

Main: To evaluate the efficacy of continuing SZC as part of the discharge medications, compared to SoC, in maintaining NK Secondary:To evaluate the effect of continuing SZC as part of the discharge medications, compared to SoC:1. in reducing the…

Stress reduction in formerly preeclamptic women; sofa or sports?

To investigate whether online mindfulness-based stress reduction (MBSR) therapy and an aerobe training intervention both leading to stress reduction and reduced circulatory risk in formerly preeclamptic women with increased mental stress levels…

A phase 3 study to evaluate the efficacy, immunogenicity, and safety of Respiratory Syncytial Virus (RSV) prefusion F subunit vaccine in adults

ObjectivesPrimary Efficacy:To demonstrate the efficacy of RSVpreF in preventing LRTI-RSV in the first RSV season following vaccination.Primary Safety:To describe the safety profile of RSVpreF as measured by the percentage of participants reporting…

A proof of concept phase II study with the PDE4 inhibitor roflumilast in people suffering from
long-term cognitive sequela after stroke

The objective is to validate the effects of chronic roflumilast treatment on cognitive function (i.e. episodic memory) by means of behavioral tasks, in people suffering from cognitive impairments at least 1 year after stroke.

The effect of collagen supplementation on collagen metabolism after total hip arthroplasty.

We aim to determine the effects of collagen supplementation on biomarkers of collagen metabolism in the two weeks following total hip arthroplasty in older adults with osteoarthritis.

Physical Exercise Prehabilitation Program in mEtabolic suRgery

The aim of this study is to investigate whether prehabilitation could enhance preoperative physical condition and weight loss before bariatric surgery and induce a lifestyle behavior change.

RANDOMIZED, OPEN LABEL, MULTICENTER, PHASE III STUDY OF ENTRECTINIB VERSUS CRIZOTINIB IN PATIENTS WITH LOCALLYADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER HARBORING ROS1 GENE REARRANGEMENTS WITH AND WITHOUT CENTRAL NERVOUS SYSTEM METASTASES

This study has been transitioned to CTIS with ID 2023-507494-18-00 check the CTIS register for the current data. This study will evaluate the efficacy and safety of entrectinib compared with crizotinib in patients who have NSCLC harboring ROS1 gene…

Flushing of internalized percutaneous transhepatic biliary drainage catheters

To compare the median time-to-symptom-onset in patients with an internal external PTBD catheter without daily flushing compared to median time-to-symptom-onset in patients with an internal external PTBD catheter who daily flush the catheter.Symptoms…

Phase 1-3, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ION373 in Patients with Alexander Disease

This study has been transitioned to CTIS with ID 2024-510603-11-00 check the CTIS register for the current data. Primary Objective: To evaluate the efficacy of ION373 in improving or stabilizing gross motor function in patients with Alexander…

Effectiveness and cost-effectiveness of TORIC intraocular lens implantation in patients with mild astigmatism

The primary aim is to evaluate the effectiveness of bilateral toric IOL implantation versus bilateral monofocal IOL in patients that undergo cataract surgery and have a predicted residual refractive astigmatism >=0.75 and <=1.50D.

A first-in-human, randomized, double-blind, placebo-controlled study to evaluate, single ascending doses of CIT-013 in healthy volunteers with and without an intravenous lipopolysaccharide challenge and repeat dosing in healthy volunteers and patients with Rheumatoid Arthritis.

Objectives Part A: • To evaluate the safety and tolerability of CIT-013 after administration of single, ascending, IV doses in healthy volunteers.• To evaluate the pharmacokinetics of CIT-013 after administration of single, ascending, IV doses in…

A Multicenter, Randomized, Double-Blind, Placebo Controlled, Parallel Group Study to Evaluate the Efficacy, Safety, and Tolerability of Soticlestat as Adjunctive Therapy in Pediatric and Young Adult Subjects With Dravet Syndrome (DS)

Primary Objectives:• To assess the efficacy of soticlestat in reducing convulsive seizure frequency as add-on therapy to SOC as compared with placebo during the full treatment period (titration + maintenance).• To assess the efficacy of soticlestat…

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy, Safety, and Tolerability of Soticlestat as Adjunctive Therapy in Pediatric and Adult Subjects With Lennox-Gastaut Syndrome (LGS)

Primary Objectives:• To assess the efficacy of soticlestat in reducing major motor drop (MMD) seizure frequency as add-on therapy to SOC as compared with placebo during the full treatment period (titration + maintenance).For European Medicines…

A Randomized Controlled Trial on Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy

To improve survival after recurrence in patients with isolated local PDAC recurrence using local ablative treatment with SBRT inaddition to standard of care.

Symptomatic niches for laparoscopic niche resection, a randomized clinical trial

Set up an RCT to study whether a laparoscopic niche resection is superior over hormonal therapy as treatment of niche-related gynaecological complaints for women with a large symptomatic niche, and without a child wish.

Potential effects of ileo-colonic delivered Vitamins or the Groningen Anti-Inflammatory Diet on course of Crohn*s Disease and the microbiome of healthy volunteers: a randomized controlled trial - The Vita-GrAID study

The main aim is to investigate the effect of a dietary intervention on CD patients and healthy volunteers. The dietary interventions consist of the Groningen anti-inflammatory diet (GrAID) and a vitamin B2/B3/C supplement (ColoVit) and they will be…