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Effects of homebased training with telemonitoring guidance in low to moderate risk patients entering cardiac rehabilitation

The objective of the present study is to investigate whether home-based exercise training with telemonitoring guidance results in improved long-term physical fitness and higher activity levels than regular centre-based exercise training in patients…

Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus

Study 1:1) To test the hypothesis that Liraglutide improves cardiovascular function in DM2 patients and whether the improvement is associated with redistribution of ectopic fat stores. 2) To test the hypothesis that Liraglutide activates BAT in DM2…

The supplementary role of cardiovascular magnetic resonance imaging and computed tomography angiography to routine clinical practice in suspected non-ST elevation myocardial infarction.
A randomized controlled trial.

Primairy objectives:1.To investigate whether a non-invasive imaging guided strategy (either CTA or CMR) early in the diagnostic process reduces the number of patients with at least one ICA during the initial admission as compared to routine clinical…

A clinical outcomes study to evaluate the effects of IL-6 receptor blockade with tocilizumab (TCZ) in comparison with etanercept (ETA) on the rate of cardiovascular events in patients with moderate to severe rheumatoid arthritis (RA).

Primary ObjectiveThe primary objective of this study is to compare prospectively in patients treated with TCZ or etanercept (ETA), the time to first occurrence of any component of a composite of major adverse cardiovascular events (MACE) consisting…

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, SAFETY, TOLERABILITY AND PHARMACOKINETIC STUDY OF SINGLE INTRAVENOUS DOSES OF GNX-5086 IN HEALTHY SUBJECTS

The purpose of the study is to investigate to what extent GNX-5086 is tolerated. It will also be investigated how quickly and to what extent GNX-5086 is absorbed and eliminated from the body (this is called pharmacokinetics).

Comparison of the ABSORB TM Everolimus Eluting Bioresorbable Vascular Scaffold System With a Drug- Eluting Metal Stent (XienceTM) in Acute ST-Elevation Myocardial Infarction

The primary objective of this study is to assess the neointimal healing score (as evaluated by intra-coronary OFDI) in patients with STEMI and treated with Abbott Vascular ABSORB everolimus eluting bioresorbable vascular scaffold (BVS) at 6 months…

Randomized clinical trial for an extended cardiac rehabilitation program using telemonitoring

To assess whether an extension of the cardiac rehabilitation program with telemonitoring guidance results in better long term effects on physical and mental outcomes than a regular follow-up period after traditional cardiac rehabilitation.

Cardiovascular outcomes study to evaluate the potential of aleglitazar to reduce cardiovascular risk in patients with a recent acute coronary syndrome (ACS) event and type 2 diabetes mellitus (T2D)

To determine whether aleglitazar reduces cardiovasculair mortality and morbidity (defined as non-fatal myocardial infarction (MI) and non-fatal stroke) in patients with a recent ACS event and type 2 diabetes.

A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL
EVALUATING THE SAFETY AND EFFICACY OF EARLY TREATMENT WITH
EPLERENONE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

To assess the impact of eplerenone on cardiovascularmortality and morbidity in patients with acutemyocardial infarction (STEMI) when initiated withinthe first 24 hours of onset of symptoms (preferablyduring the first 12 hours)To investigate the…

A pivotal trial of safety and efficacy of ADRCs delivered via the intracoronary route in the treatment of patients with ST-elevation acute myocardial infarction â¤* The ADVANCE Trial

The objective of this study is to determine the Safety and Efficacy of ADRCs delivered via the intracoronary route in the treatment of patients with ST-elevation acute myocardial infarction (STEMI).Investigation of stem and regenerative cell therapy…

A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of 2 Doses of RO4905417 (R1512) Administered to Patients with Non ST-Elevation Myocardial Infarction (Non-STEMI) Undergoing Percutaneous Coronary Intervention (PCI)

The primary efficacy objective of this study is:• To evaluate the efficacy of RO4905417 in reducing the procedural damage during PCIThe secondary efficacy and safety objectives of this study are: • To evaluate the changes in other cardiac and renal…

Randomized controlled trial of mindfulness training as complementary therapy in adults with structural heart disease

Objective of this study is to determine (1) whether mindfulness training has an additional clinical and psychological effect to standard care, and (2) whether offering mindfulness training is a cost-effective intervention, in adult patients with…

Randomized Clinical Trial for optimal Cardiac Rehabilitation: A traditional Dutch Cardiac Rehabilitation Program versus a Canadian High Efficiency Cardiac Rehabilitation Program

To assess the suitability of the (HR)2 programme in the Dutch setting and compare the efficiency of the (HR)2 programme with traditional cardiac rehabilitation in the Netherlands.

*MGuard* Prime Stent System Clinical Trial in Patients with Acute ST Elevation Myocardial Infarction*.

The objective of this study is to evaluate the safety and efficacy of the MGuard* Prime stent in the treatment of de novo stenotic lesions in coronary arteries in patients undergoing primary PCI due to acute STEMI as compared with BMS or DES in the…

Immunoglobulin therapy for patients with idiopathic cardiomyopathy and endomyocardial parvovirus B19 persistence - a prospective, double-blind, randomized, placebo-controlled clinical trial

A controlled trial to investigate whether high dose of intravenous immunoglobulin (IVIg) in addition to conventional heart failure therapy in patients with idiopathic cardiomyopathy and PVB19 persistence in the heart achieves improvement of cardiac…

A multicenter randomized controlled study of mechanical left ventricular unloading with counterpulsation to reduce infarct size pre PCI for acute myocardial infarction- CRISP-AMI.

To investigate if infarct size can be limited by introduction of IABP prior to intervention.

Acute and chronic administration of the folate derivate levofolinate to patients with acute myocardial infarction: A double-blinded placebo-controlled pilot study.
"Folate in Acute Myocardial Infarction (FolAMI-study)"

A controlled trial to investigate whether by reducing eNOS uncoupling, by direct super oxide scavenging and by up regulating the high-energy phosphate pool, a high dose of intravenous levofolinate can reduce ischemia- and reperfusion-induced…

A clinical trial comparing treatment with cangrelor (in combination with usual care) to usual care, in subjects who require percutaneous coronary intervention

The primary objective of this study is to demonstrate that the efficacy of cangrelor (combined with usual care) is superior to that of usual care, in subjects requiring percutaneous coronary intervention (PCI) as measured by a composite of all-cause…

The effect of two different heart-lung machines, Twin-Pulse Life Support and standard used heart-lung machine, on the systemic inflammation and pattern of microvascular blood flow. A prospective randomised clinical trial.

Analysis of the effects of the Twin-Pulse Life Support on on the systemic inflammatory response and the effect on microvascular blood flow in ocmparison to standard used Extracorporeal Circuit Device

A Self-Regulation Intervention Program for Lifestyle Change in Cardiac Patients

To develop an effective lifestyle intervention for cardiac patients based on self-regulation theory aimed at health behavior change and maintenance.