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A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Safety and Efficacy Study of Dutogliptin in Combination with Filgrastim in Early Recovery Post-Myocardial Infarction

Primary ObjectiveTo evaluate the safety and tolerability of dutogliptin in combination with filgrastim in subjects with STEMI compared with placebo Secondary ObjectivesTo assess preliminary efficacy of dutogliptin in combination with filgrastim in…

Groningen Intervention study for the Preservation of cardiac function with sodium thiosulfate after ST-segment elevation myocardial infarction

To evaluate the efficacy and safety of STS compared to placebo treatment on myocardial infarct size in patients presenting with STEMI and treated with PCI and in adjunction to optimal reperfusion therapy.

Reverse remodeling after PTSMA in severe but ASympTomAtic LVOT obstruction - RASTA study

Identify, if any, both structural and functional changes related to LVOT desobstruction in asymptomatic with exertional LVOT pressure gradients >50 mmHg (or >30 mmHg in rest)

A Randomized, Placebo-controlled Phase 2b Study to Evaluate the Safety and Efficacy of MEDI6012 in Acute ST Elevation Myocardial Infarction

To evaluate the effect of MEDI6012 on infarct size compared with placebo.

IOCYTE AMI-3: A Phase 3, Randomized, Double-Blind, Placebo- Controlled, Multicenter Study of Intravenous FDY-5301 in Patients with an Anterior ST-Elevation Myocardial Infarction

This study has been transitioned to CTIS with ID 2024-514372-40-00 check the CTIS register for the current data. Primary objective: To assess the effect of FDY-5301 on cardiovascular mortality and heart failure events in subjects with an anterior…

A Phase IIB, Randomized, Double blinded, Placebo controlled, Parallel
group Study to Evaluate the Efficacy and Safety of MEDI6570 in
Participants with a Prior Myocardial Infarction, Persistent Inflammation,
and Elevated N terminal Prohormone Brain Natriuretic Peptide

primaryTo evaluate the effect of MEDI6570 on non-calcified coronary atherosclerotic plaques compared with placebosecundaryTo evaluate the effect of MEDI6570 on a surrogate biomarker of HF compared with placeboTo evaluate the effect of MEDI6570 on…

Multi-center, double-blind, randomized, placebo-controlled, parallel-group
study to evaluate the efficacy and safety of self-administered
subcutaneous selatogrel for prevention of all-cause death and treatment of
acute myocardial infarction in subjects with a recent history of acute
myocardial infarction

This study has been transitioned to CTIS with ID 2023-505438-85-00 check the CTIS register for the current data. The primary objective of the study is to assess the clinical efficacy of selatogrel when self-administered upon occurrence of…

Optimizing patient experience during cardiac stress testing

Primary objective: To determine whether adding information and coaching support to the standard diagnostic testing environment for the inducibility of myocardial ischemia improves patient psychological wellbeing.The role of the testing environment…

EMPACT-MI: A streamlined, multicentre, randomised, parallel group, double-blind placebo-controlled superiority trial to evaluate the effect of EMPAgliflozin on hospitalisation for heart failure and mortality in patients with aCuTe Myocardial Infarction

The main objective of this event-driven trial is to demonstrate the superiority of empagliflozin 10 mg once daily versus placebo, in addition to standard of care, for the reduction of the composite endpoint of time to first heart failure…

A Phase 3 prospective, blinded, randomized, placebo controlled, international multicenter study to assess the safety and efficacy of a single subcutaneous injection of zalunfiban in subjects with ST-elevation myocardial infarction in the pre-hospital setting

This study has been transitioned to CTIS with ID 2023-508485-15-00 check the CTIS register for the current data. Main study:Primary:Efficacy:- To assess the clinical outcome at 30 days follow-up after administration of a single subcutaneous…

Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction. The STEMI-DTU Pivotal trial.

Demonstrate that primary Left Ventricular unloading and a thirty-minute delay-to-reperfusion, when compared to the control cohort, treated according to the current standard of care treatment of Anterior STEMI, has the following effects:1. Reduction…

BIO monitoring in patients with preserved left ventricular function after diagnosed acute Myocardial
Infarction.

The objective of the the BIO|GUARD-MI study is to investigate whether the early diagnosis of cardiac arrhythmias, provided by the BioMonitor in connection with remote monitoring, and the consequent treatment of the patient will decrease the risk to…

A phase III, double-blind, randomized placebo-controlled study to evaluate the effects of dacetrapib on cardiovascular (CV) risk in a genetically defined population with a recent Acute Coronary Syndrome (ACS): The dal-GenE trial

The primary objective of this trial is to evaluate the potential of dalcetrapib to reduce cardiovascular morbidity and mortality (cardiovascular death, resuscitated cardiac arrest, non-fatal myocardial infarction (MI) and non-fatal stroke) in…

Angiotensin inhibitors during the perioperative period: to withdraw or to continue?

The objective of the proposed trial is therefore to determine the effect of continuation versus withdrawal of ACEi and ARB in the perioperative period on postoperative complications, expressed as acute kidney injury, myocardial injury, and quality…

Multicenter, randomized, placebo controlled, double-blind, parallel group, dose-finding Phase 2 study to evaluate the efficacy and safety of BAY 2433334 in patients following an acute myocardial infarction

Primary Objective:- to evaluate whether the oral FXIa inhibitor BAY 2433334 leads to a lower incidence of CV death, MI, stroke and stent thrombosis following an acute myocardial infarction when compared to a placebo- to evaluate whether the…

The effect of proactive versus reactive treatment of hypotension on postoperative disability and outcome in surgical patients under anesthesia (PRETREAT): an adaptive, multicenter randomized controlled trial

The aim of this adaptive multicentre randomized controlled trial is to maintain patients at a target blood pressure level with a sufficient margin from the minimal acceptable blood pressure threshold of a MAP of 65 mmHg to reduce the incidence of…

Quantitative-imaging in cardiac transthyretin amyloidosis (I-CARE)

This study has been transitioned to CTIS with ID 2024-513310-36-01 check the CTIS register for the current data. Primairy objectives 1. To determine the presence and extent of myocardial microcalcification and myocardial denervation in ATTR-CM;2. To…

PROFID EHRA
PRevention Of sudden cardiac death aFter myocardial Infarction by Defibrillator im-
plantation

To demonstrate that in post-MI patients with symptomatic heart failure who receive optimal medical therapy (OMT) for this condition, and with reduced LVEF <=35%, OMT without implantable cardioverter defibrillator (ICD) implantation (index…