Search for a trial

A randomized, double-blind, placebo-controlled study to compare the immune effects of multiple doses of vitamin D3 in patients with allergic rhinitis/rhino-conjunctivitis caused by birch pollen and in healthy control subjects.

The primary objective is to evaluate whether 2.5 µg VD3 analogue (Zemplar® * Abbvie) in multiple subcutaneously administered doses induces a more favourable (read: anti-inflammatory) systemic immune modulation both in general parameters and allergen…

Butyrate Use in TYpe 1 diabetes: effects on Regulation of bActerial translocation, innate immunity, T-cell function and Endotoxemia

To investigate whether ingestion of 4 grams of butyrate daily during 4 weeks can positively affect the immune system function, residual betacell function and low grade inflammation in patients with type 1 diabetes mellitus.

Effect of the addition of pre-biotics to infant formula on markers of immune development and atopy at 5 years of age

are there differences in levels of IgE and sub-classes, TARC ,light chain IgG and titers against vaccins HiB and Tetanus between children who received as infant a formula with or without pre-biotics ?

The Inca study: Impact of Nutrition on Children with ADHD. A randomised, controlled trial into the effects of a few foods diet on the behaviour of a heterogeneous, not selected group of primary school children, meeting the DSM-IV-criteria of ADHD

1. Randomised controlled determination of the influence of foods on the behaviour of a heterogeneous not-selected group primary school children, during the first two months of the trial. 2. Determination of an IgG or IgE-mediated respons to foods,…

Tolerance induction in cow's milk allergy

The project is focused on induction of immune tolerance in allergy by prebiotics. The pathophysiology of immune modulation will be investigated and searched for potential biomarkers for immune modulation.

A study proposal to investigate the sequels of mucosal inflammation caused by ETEC infection- the effects of probiotics

The main objective of this study is to investigate the effect of probiotics on the sequels of ETEC administration as intestinal permeability, inflammation and clinical signs as total faecal output, relative faecal dry weight and mucin excretion in…

Effect of mechanical ventilation on plasma cytokine concentrations in healthy humans

Our primary goal is to compare the effects of a positive pressure mechanical ventilation with spontaneous breathing on systemic cytokine release in patients with normal pulmonary function. Secondly, the possible effects of surgery on the ventilation…

*Fragrance allergy and skin tolerability to essential oils*

Primary Objective: What is the frequency of positive patch test reactions to the 26 declarable fragrance allergens in fragrance mix I and/or II positive participants?Secondary Objectives: Do Weleda cosmetic products containing essential oils,…

Bosentan (Tracleer®) in patients with Behçet*s disease: a Pilot Study.

· To determine therapeutic efficacy of Tracleer in patients with active Behcet disease. Furthermore:· To study cytokine and immunological patterns and ET-1levels in those patients.

Regulation of the stress-axis by vitamin D3 in subjects with multiple sclerosis; a double-blinded, randomized, placebo-controlled study

The main aim of this study is to assess hypothesis A, and we will perform an exploratory analysis on hypothesis B.

A phase IV, interventional, non-blinded, randomized, controlled, multicenter study of posaconazole prophylaxis for the prevention of influenza-associated aspergillosis (IAA) in critically ill patients

To deliver proof of concept that antifungal prophylaxis with posaconazole in addition to standard of care (SOC) can reduce the incidence of IAA in ICU patients with severe influenza, in comparison with SOC alone.To assess differences in cytokine…

The effects of human endotoxemia on the functional capacity of hematopoietic stem and progenitor cells

Primary objective: - To characterize hematopoietic progenitor cells in human bone marrow before and after endotoxemia (by evaluating hematopoietic lineage differentiation and functional capacity). Secondary Objectives: - To determine the effects of…

A randomized trial to investigate the reset of humoral autoimmunity by combining belimumab with rituximab in severe systemic lupus erythematosus

The primary objective is to assess whether combination treatment BLM+RTX will lead to reduced treatment failure and the improvement of pivotal, SLE-specific autoimmune phenomena compared SLE patients treated with standard of care.

*Effect of addition of elemental nutrition to an elimination diet on esophageal inflammation in adult eosinophilic esophagitis (EoE) patients: A randomized controlled trial

To investigate whether addition of amino acid-based nutritional supplements to FFED is more effective in reducing esophageal eosinophilic inflammation measured as reduction in absolute number of eosinophils than FFED alone, in adult EoE patients.