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Uniform FDG-PET guided gradient dose prescription to reduce late radiation toxicity (UPGRADE RT): a randomised controlled trial with dose reduction to the elective neck in head and neck squamous cell carcinoma

The UPGRADE-RT trial will investigate whether de-escalation of the elective radiation dose and introduction of an intermediate dose-level in the treatment of head and neck cancer will results in less radiation sequelae and improved quality of life…

A phase 1, placebo-controlled, single ascending-dose study to assess the safety, tolerability and pharmacokinetics of OTL-038 injection in healthy volunteers

Primary objective:To assess the safety, tolerability and pharmacokinetics of a single IV dosages of OTL-038. Selected doses of OTL-038 will be studied in the absence and presence of prophylactic treatment with the antihistamine clemastine to be…

Optimization FDG-uptake in myocard with a low-carbohydrate diet

To evaluate if a low-carbohydrate diet leeds to less physiological FDG-uptake in the myocard. Patients on a low-carbohydrate diet will be compared to patients without such a diet.

Forward viewing US endoscope versus standard oblique viewing US endoscope in the performance of EUS-guided fine needle aspiration of solid lesions of the gastrointestinal tract and of adjacent organs: A prospective randomized controlled study

The primary aim of the study is to compare the performance of the standard oblique-viewing US endoscope versus a prototype forward viewing ultrasonic endoscope for EUS-FNA of solid lesions of the GI tract and of adjacent organs.

ESTABLISHING THE DIAGNOSTIC AND PROGNOSTIC ROLE OF NARROW BAND IMAGING
IN HEAD AND NECK CANCER

to establish the diagnostic and prognostic value of Narrow band Imaging (NBI) in head and neck cancer

Immune Related Rheumatological Adverse Events.
Data collection from patients with cancer to evaluate rheumatological adverse events in patients treated with immune-checkpoint inhibitors.

This study has been transitioned to CTIS with ID 2024-516631-27-00 check the CTIS register for the current data. The evaluation of R-IrAE's after ICI therapy, specifically incidence, treament of R-IrAE's, response to said treatment,…

Personalized elective neck irradiation guided by sentinel lymph node biopsy in patients with squamous cell carcinoma of the oropharynx, larynx or hypopharynx with a clinically negative neck: (chemo)radiotherapy to the PRIMary tumor Only. The PRIMO study.

To compare safety and efficacy of treatment with sentinel lymph node biopsy guided elective neck irradiation versus standard elective neck irradiation in patients receiving definitive (chemo)radiotherapy for squamous cell carcinoma of the oropharynx…

The relationship between contrast media volume and tube voltage in computed tomography of the liver, for optimal enhancement based on total body weight: A randomized controlled trial. [COMpLEx trial]

The aim of present study is to investigate if adapting the dosing factor based on TBW and therefore the CM volume to the tube voltage used, results in a more homogeneous liver enhancement. We hope to find a more homogeneous enhancement between…