21 results
The objective of the study is to determine if virtual reality exposure therapy (VRET) is an effective treatment for enhancing social participation in people with a psychotic disorder or generalized social anxiety disorder. The primary objective is…
Primary objective of the study is to investigate whether Behavioral Activation for Negative Symptoms (BANS) improves negative symptoms. Secondary objective is to investigate whether effects of BANS on negative symptoms is mediated or moderated by…
To evaluate the applicability and (cost-) effectiveness of a shortened, partly group based, Cognitive Behavioural Therapy (CBTsa) focussing on social activation in patients with recent onset schizophrenia.
The primary objective of this study is to evaluate in a randomized controlled clinical trial the clinical effectiveness of TAT on the proportion of medication non-adherent patients over 24 months, in schizophrenia outpatients who have poor…
This study aims to investigate the effectiveness of the CARe methodology in terms of rehabilitation, participation, empowerment, hope and confidence, fullfilled needs for care and quality of life. The central research question is: *Does the support…
Primary objective of this study is to investigate if the Metacognitive Reflection and Insight Therapy (MERIT) improves metacognitive abilities in people with schizophrenia. Secondary objective is to examine whether improvement in metacognitive…
The following research questions are formulated:A. Does exposure to cannabis (THC) result in an increased dopamine response in the striatum (as measured with PET)? And does cannabis use lead to an increase in psychotic experiences or symptoms?B. Do…
The aim of this study is to determine whether the treatment is effective in reducing symptoms in patients suffering from AVH*s.
The aim of the proposed study is to investigate the effects of antipsychotic medication on total brain volume and specific brain structures known to be affected in schizophrenia, such as hippocampus, thalamus, caudate, parietal and prefrontal cortex…
To test the effect of a novel VR treatment for social interaction difficulties (VR-SOAP) on quantity and quality of social contacts, leisure activities and social participation of young people with a psychotic disorder. Furthermore, to investigate…
The main objective of this study is to investigate the feasibility of a larger single-blind, randomized trial focused on (cost) effectiveness and safety of ECT vs. aripiprazole addition in patients with schizophrenia spectrum disorders (SSD)…
Our primary objective is to test the effects on researcher-rated severity of PTSD symptoms of a full dose of prolonged exposure therapy (PE), eye movement desensitization and reprocessing therapy (EMDR), cognitive restructuring therapy without…
Primary Objective: To test whether the Feeling Safe-NL programme is more effective in improving wellbeing over time than CBTp (from baseline to 18-month follow-up).Secondary objectives: To test whether the Feeling Safe-NL programme is more effective…
The primary objective of the study is to determine whether DiSCoVR improves social cognition. We are interested in the effect of DiSCoVR on the following social cognitive domains:- Emotion Perception.- Social Perception.- Theory of Mind.The second…
To investigate if VRcbt is more (cost-)effective than standard CBT for treatment of paranoid delusions and improving daily life social functioning of patients with schizophrenia and related psychotic disorders.
The main goal is to investigate whether COMET can be used as an intervention to reduce paranoia in patients with psychotic disorder and paranoid thoughts. An aim is also to see if the treatmenteffect is stable after eight weeks.
This study aims to examine the effectiveness, feasibility, and applicability of the adapted and translated CR from Mullen and colleagues (2017), named Mindset, for students with psychotic problems in the Netherlands.
The primary objective is to test the effects of temstem on distress, disturbance to life and social functioning. Second, we aim to investigate the effect of temstem on frequency and severity of AVH, to determine working mechanisms, to identify…
The current project aims to investigate the efficacy of a new form of treatment that integrates ACT in the daily-lives of ARMS individuals using a small digital device (PsyMate®). We hypothesise the ARMS and FEP individuals who receive the…
The overall aim of the current study is to investigate the efficacy and clinical feasibility of a novel, accessible, transdiagnostic, ecological momentary, compassion-focused intervention for improving emotional resilience to stress (*EMOCOMPASS*)…