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Clinical feasiblity and efficacy of intermittent use of a fasting mimicking diet in the treatment of type 2 diabetes

To evaluate the clinical feasibility and effectiveness (in terms of metabolic parameters and cost-effectiveness) of intermittent use of a fasting mimicking diet in patients with type 2 diabetes mellitus compared to usual care.

Check@Home: General population screening for early detection of atrial fibrillation and
chronic kidney disease

The Check@Home consortium aims to set up a roadmap and infrastructure for a (cost-)effective program to early detect atrial fibrillation and chronic kidney disease (defined by elevated albuminuria) in the general population. Furthermore, the project…

Effect of Mediterranean diet combined with healthy food boxes on blood glucose levels of people with type 2 diabetes and low socioeconomic status: a randomized controlled trial

Primary Objective: What is the difference in the effectiveness of the Food Pharmacy Program in glycaemic regulation compared to nutrition coaching performed by dieticians after three months in overweight adults with type 2 diabetes? Secondary…

A double-blind, randomised, placebo-controlled, parallel group trial to evaluate the efficacy and safety of empagliflozin and linagliptin over 26 weeks, with a double-blind active treatment safety extension period up to 52 weeks, in children and adolescents with type 2 diabetes mellitus

DINAMOTM (main study)The objective of this study is to assess the efficacy and safety of anempagliflozin dosing regimen and one dose of linagliptin versus placebo after 26 weeks of treatment in children and adolescents with type 2 diabetes mellitus…

Carbohydrate induced resilience of the gut microbiome after antibiotics use

The objective of this study is to investigate the potential of a dietary fiber, 2'-fucosyllactose (2'-FL), to improve gut microbiome resilience after antibiotics use.Furthermore it will also be investigated whether there is a link between…

Investigation of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of NNC0480-0389 in combination with semaglutide s.c.

The purpose of this study is to investigate how safe, and how well tolerated, the new study drug NNC0480-0389 is when it is given together with semaglutide. It will also be investigated how quickly and to what extent NNC0480-0389 and semaglutide are…

A first-in-human, randomized, double-blind, placebo-controlled, study to evaluate the safety, tolerability, and pharmacokinetics of single ascending oral doses of GLPG4059 in adult, healthy, male subjects.

This study will be performed in a maximum of 57 healthy male volunteers. The study will be performed in 2 parts, Part 1 and Part 2. Part 1 will consist of a maximum of 6 groups of 8 volunteers each. The volunteers can participate in one of these…

Time restricted eating to treat gestational diabetes mellitus

To determine the effect of time restricted eating in gestational diabetes on glucose metabolism.

'Study on infant Adiposity development To Understand the Role of early life Nutrition - the Sophia Saturn Study'

Primary Objective:To investigate change in fat mass index between 6 and 12 months of age in infants receiving Nuturis® formula feeding versus standard formula feeding during the first 6 months of life.Secondary Objectives:- To investigate change in…

Towards the development of a personalised E-Health intervention for use in community pharmacies to analyse and improve medication non-adherence in people with type 2 diabetes mellitus, who are non-adherent to oral blood glucose and/or blood pressure lowering drugs.

The main objective of this study is to develop and investigate the (cost-) effectiveness of a pharmacist-led personalised intervention, with E-Health components, to analyse and improve medication adherence in people with T2DM, who are non-adherent…

A randomized controlled multicenter trial comparing bariatric surgery with a structured life style intervention program in subfertile obese women with PCOS

It is hypothesed that intervention (bariatric surgery) compared with control (life style intervention program) will increase fertility measured by the healthy born baby rate after at least 37 weeks of gestation (primary end point) within 3 years…

Effect of oral Eubacterium Hallii on postprandial glucose metabolism in males with type 2 diabetes treated with metformin

to investigate the effect of 14 days once daily oral Eubacterium hallii (E. hallii) treatment on postprandial glucose levels in relation to SCFA levels in feces in patients with type 2 diabetes treated with metformin.

SOUL: Semaglutide cardiovascular outcomes trial in patients with type 2 diabetes

The primary objective is to demonstrate that oral semaglutide lowers the risk of major adverse cardiovascular events compared to placebo, both added to standard of care in patients with type 2 diabetes and at high risk of cardiovascular events.The…

Efficiency of a blended care version of an effective diabetes diet

Primary Objective: 1. What is the efficiency of a blended care version of the POWER diet (Blended POWER), compared to the POWER diet used in usual care (usual care POWER program): is Blended POWER equally effective in reducing weight after 1 year in…

A randomized control trial to assess if changing sleep timing can improve glucose metabolism in people with (pre)diabetes

To investigate whether a reduction in social jetlag for 3 weeks can improve glycemic and metabolic control, sleep, mood and quality of life in people with (pre)diabetes.

The effect of a single session of whole-body neuromuscular electrical stimulation (NMES), with or without subsequent intake of a protein bolus, on whole-body protein turnover in sedated intensive care unit (ICU) patients

To examine the effect of a single session of whole-body NMES, with or without subsequent protein intake, on whole-body protein turnover

Prevention of diabetes with a novel butyrate-enriched triglyceride

Primary Objective:The main goal of the study is to investigate the effects of a chronic increase in the gut microbial metabolite butyrate and hexanoate in the systemic circulation on peripheral insulin sensitivity in individuals with overweight/…

The Diabetes Body Project: Multi-site trial of a virtually delivered eating disorder prevention program for young females with type 1 diabetes

We aim to investigate the efficacy of a novel eating disorder prevention program, the Diabetes Body Project, specifically targeting young females T1D. Firstly, we will test the hypothesis that Diabetes Body Project will produce significantly greater…

Efficacy and safety of once weekly insulin icodec compared to once daily insulin degludec 100 units/mL, both in combination with insulin aspart, in adults with type 1 diabetes.;A 26-week, randomised, multicentre, open-label, active-controlled, parallel group, two armed, treat-to-target trial investigating the effect on glycaemic control and safety of treatment with once weekly insulin icodec compared to once daily insulin degludec, both in combination with insulin aspart in adults with type 1 di

Primary objectiveTo confirm the effect on glycaemic control of once weekly insulin icodec in combination with insulin aspart, in subjects with T1D. This includes comparing the difference in change from baseline in HbA1c between once weekly insulin…

Efficacy and safety of oral semaglutide versus placebo both in combination with metformin and/or basal insulin in children and adolescents with type 2 diabetes

This study has been transitioned to CTIS with ID 2023-506923-27-00 check the CTIS register for the current data. Primary objectiveTo confirm superiority of oral semaglutide at the maximum tolerated dose* (3 mg, 7 mg or 14 mg) versus placebo on…