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A Randomized Clinical Trial of Cutaneous Xylocaine Spray to Reduce Intravenous Cannulation Pain in Adults.

Objective: Adequate analgesia during intravenous cannulation.Hypothesis: Xylocaine spray for the placement of an infusion decreases the pain score with two or more points in comparison to placebo spray.Studie questions:Primary: Has xylocaine spray…

Deep and slow breathing in postsurgical abdominal pain management: an explorative study

To investigate whether deep and slow breathing exercises can reduce pain induced by mobilizing from bed to chair after major abdominal surgery, compared to a reading task.

Employing dynamic kinetic responses to demonstrate the effectiveness of dietary intervention: A challenge-based study using a low-glycaemic load diet

Primary objective: To assess the impact of a low glycaemic load (GL) diet as compared to a *Western* diet on metabolic flexibility (the change in RQ) upon a hyperinsulinemic euglycemic clamp. Secondary objectives: 1) To assess the impact of low GL…

From expecting to experiencing: The role of parenting cognitions in the transition to parenthood

Study 1 is aimed to describe normative trajectories of parenting efficacy from pregnancy to early parenthood. Study 2 is focused on the question whether mental representations of attachment are protective in the context of parenting stress and its…

The effect of an interdental brush and a water flosser on gingival bleeding and gingival abrasions. A 4 weeks randomized clinical trial.

Primary objective: - What is the effect of the commercially available Water Flosser compared to interdental brushes evaluating gingival bleeding in a group of systemically healthy participants with gingivitis but without periodontitis?Secundary…

The effect of concentrated beetroot juice with or without vitamin C on the levels of N-nitroso compounds in urine

The main aim of the study will be to compare the urinary N-nitroso compounds levels after intake of 70 ml of concentrated red beetroot juice containing 400 mg nitrate either with or without supplementation with 1 g vitamin C.

Effects of prophylactic use of haloperidol in critically ill patients with a high risk for delirium

In this study we aim to examine the effects of a low dosage of prophylactic haloperidol in patients with an expected ICU length of stay of >1 day. We use two different dosages of haloperidol in this study to compare with placebo. A dosage of…

Mini-internet training in positive reappraisal and concrete thinking for adolescents

This study aims to compare the effects of a training in concrete thinking and a training in positive reappraisal with a control conditions (no specific training instructions) on indices of psychological wellbeing in youth aged 15 to 18. Participants…

A 24 month, multicenter, randomized, open-label safety and efficacy study of concentration-controlled everolimus with reduced calcineurin inhibitor vs mycophenolate with standard calcineurin inhibitor in de novo renal transplantation- Advancing renal TRANSplant eFficacy and safety Outcomes with an eveRolimus-based regiMen (TRANSFORM)

Primary: to evaluate the effect of everolimus with reduced exposure CNI versus MPA with standard exposure CNI on the binary composite of treated biopsy-proven acute rejection (tBPAR) or eGFR < 50mL/min/1.73m2 at Month 12 post-transplantation.…

MEtoclopramide, DExamethasone or Aloxi (palonosetron) for the prevention of delayed chemotherapy-induced nausea and vomiting in moderately emetogenic non-AC-based chemotherapy: the MEDEA trial

In this phase III non-inferiority trial, the aim is to evaluate whether metoclopramide and palonosetron prophylactic antiemetic treatment are non-inferior to dexamethasone with regard to its efficacy to prevent delayed CINV induced by non-AC based…

SUCCESS STUDY; Smoking reduction by a smoking cessation strategy in the national cervical cancer screening program

We hypothesize that a smoking cessation strategy for smoking cervical cancer screening participants will increase their motivation to quit and will lead to an increased proportion of smokers performing a serious quit attempt. Eventually this will…

The effect of the carotenoid-producing Bacillus strain PD01 on cardiovascular health and microbial environment

Phase 1: To assess the safety of carotenoid-producing Bacillus strain PD01 administered orally once daily in healthy volunteers for 14 consecutive days. Phase 2: To determine the effects of daily administration of a carotenoid-producing Bacillus…

*Unravelling the effectiveness of a behaviour change intervention to enhance physical activity in nurse-led cardiovascular risk management: study protocol of a clustered-randomized controlled trial in primary care*

The main objective of this study is to evaluate the effectiveness of the Activate intervention in adult patients at risk for cardiovascular disease (CVD) in primary care. Secondary aims are to identify which patient-related characteristics modify…

The effect of UVB irradiation compared with oral vitamin D supplementation on well-being in psycho-geriatric nursing home residents in the Netherlands

Comparing the additional effects of UVB irradiation to oral vitamin D supplementation on well-being and quality of life in psycho-geriatric nursing home residents.

Effect of Health games on Cognitive Function in Parkinson*s Disease

The main aim of this phase-II-proof-of-principle study is to test whether the health game AquaSnap offers improvement of cognitive impairment in PD patients with mild cognitive impairment, using an RCT. The long-term ambition is to test whether the…

Effect of Sodium NItroprusside (SNP) on R,S- and S-Ketamine-induced psychotropic side effects, hemodynamic changes and pain relief in healthy volunteers

The objectives of the study are to assess whether:(1) SNP will reduce the occurrence of psychomimetic side effects during exposure to low-dose ketamine;(2) SNP will reduce the ketamine-induced increase in blood pressure and cardiac output;(3) SNP is…

When is the best moment to remove the urinary catheter
after laparoscopic hysterectomy? A multicentre randomized controlled trial comparing direct versus delayed removal

The aim of this study is to evaluate if direct removal of the urine catheter after an LH (total laparoscopic hysterectomy and laparoscopic supracervical hysterectomy) is associated with similar (or better) outcomes compared to catheter removal the…

The effect of olive leaf extract administration on cardiovascular health

The objective of this study is to investigate the effect 8-week OLECOL supplementation on cardiovascular risk markers.

Blood glucose monitoring, cognition, and wellbeing in relation to food intake @ work * a pilot study

The primary objective of this pilot study is to investigate the relationship between glucose and cognition and wellbeing in an at-work setting. Additionally, this study aims to investigate the variability in intra- and inter individual glucose…

*Once you pop, you just can*t stop*: how mindset rules biology and makes you eat

The main goal of the current project is to study whether a mindset of perceived control / loss of control over intake affects hormone release, brain reward processing, desire to eat and actual consumption.