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TIGER-3: A Phase 3, Open-label, Multicenter, Randomized Study of Oral
Rociletinib (CO-1686) Monotherapy Versus Single-agent Cytotoxic
Chemotherapy in Patients with Mutant EGFR Non-small Cell Lung Cancer
(NSCLC) After Failure of at Least 1 Previous EGFR-directed Tyrosine Kinase
Inhibitor (TKI) and Platinum-doublet Chemotherapy

Primary Objective• To compare the anti-tumor efficacy of oral single-agent rociletinib, as measured by investigator assessment of the progression-free survival (PFS), with that of single-agent cytotoxic chemotherapy in patients with EGFR mutated,…

A twelve week, open-label, randomised, parallel-group study evaluating safety, tolerability and pharmacokinetics (PK) of oral nintedanib in combination with oral pirfenidone, compared to treatment with nintedanib alone, in patients with idiopathic pulmonary fibrosis (IPF)

The main objective of the trial will be to assess safety and tolerability of combined treatmentwith nintedanib and pirfenidone.A secondary objective is to assess the exposure based on PK trough concentration values tonintedanib either given alone or…

A Phase 2 Trial to Evaluate the Efficacy of PRM-151 in Subjects with Idiopathic Pulmonary Fibrosis (IPF)

To determine the effect size of PRM-151 relative to placebo in change from Baseline to Week 28 in mean FVC% predicted, pooling subjects on a stable dose of pirfenidone or nintedanib and subjects not on other treatment for IPF.

A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Dupilumab in Patients with Severe Steroid Dependent Asthma

Primary objective: To evaluate the efficacy of dupilumab, compared with placebo, for reducing the use of maintenance oral corticosteroids (OCS) in patients with severe steroid-dependent asthma.Secondary objectives:To evaluate the safety and…

Prevention of exacerbations in patients with COPD through vitamin D supplementation: a randomized controlled trial

To assess the effect of vitamin D supplementation on exacerbation rate in patients with COPD and a vitamin D deficiency.

The role of dynamic hyperinflation in asthma

Primary objective: To investigate the effect of supplementation of a single intramuscular dose of 80 mg triamcinolone on the level of MPT-induced dynamic hyperinflation, in adult asthma patients with demonstrated dynamic hyperinflation. (Part 1)…

What is the effect of steppen (stepping on and off at aerobicsstep) at quality of live, endurance, hospitalization stay and muscle strenght of the quadriceps and circumference of the calf muscles during hopitalized COPD exacerbation relative to the standard therapy?

The aim of the research is to understand the effect of steppen on the quality of life , opnameduur , endurance , muscle strength of quadriceps and circumference of the calf muscles against the standard treatment during a clinical COPD exacerbation…

A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Multi-Center Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS-5806 in Hematopoietic Cell Transplant (HCT) Recipients with Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory Tract

The primary objective of this study is as follows:* To evaluate the effect of presatovir on RSV viral load in autologous or allogeneic HCT recipients with an acute RSV lower respiratory tract infection (LRTI)The secondary objectives of this study…

ARTEMIS: A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel-Group, Event-Driven Study to Evaluate the Efficacy and Safety of Ambrisentan in Subjects with Early Idiopathic Pulmonary Fibrosis (IPF).

The primary objective of this study is to determine if ambrisentan is effective in delaying disease progression and death in subjects with IPF.Secondary objectives include evaluation of the safety and effect of ambrisentan on development of…

Respiratory, hemodynamic and inflammatory effects of induced HypothermiA using NoVAtherm with extra corporeal membrane ventilator iLA-Activve in patients with acute respiratory distress syndrome (ARDS)

Primary Objective: Does induced hypothermia using NovathermTM combined with the iLA-Activve MinilungTm result in a reduction in minute volume ventilation and work of breathing by reducing positive peak inspiratory pressure levels in patients with…

A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating CNTO 3157 in Healthy Normal and Asthmatic Subjects Inoculated with Human Rhinovirus Type 16

The primary objective of Part 2 of this study is to determine the efficacy of pretreatment with CNTO 3157 compared with placebo in attenuating the respiratory manifestations of inoculation with HRV-16 in adult subjects with mild to moderate asthma.…

Effectiveness of routine nebulisation of mucolytic agents and bronchodilating drugs in intubated and ventilated intensive care unit patients.

To determine the efficiency, safety and health care costs of a strategy using routine nebulisation of mucolytics and bronchodilators four times daily, with a strategy of nebulisation on a strict clinical indication only, in mechanical ventilated…

A Phase 2, Multicenter, Randomized, Double blind, Parallel group, Placebo controlled Study Evaluating the Safety and Efficacy of Treatment with Ustekinumab or Golimumab in Subjects with Chronic Sarcoidosis

See above

A Randomized, Double-Masked, Sponsor-Unmasked, Ascending Multiple Dose Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PRM-151 Administered Intravenously to Patients with Idiopathic Pulmonary Fibrosis

PRM-151 is being developed for potential therapeutic use to prevent, treat and reduce fibrosis. This study will provide an assessment of the safety, tolerability, pharmacokinetics and pharmacodynamics of PRM-151 after administration of ascending…

The airway smooth muscle cell in asthma:
A genomics approach

To examine the difference in gene expression profiles of ASM in bronchial biopsy specimens between asthmatic patients, non-asthmatic allergic and non-asthmatic non-allergic controls.To associate the gene expression profiles with airway…

Physical Exercise Training Programme COPD in Primary care

1) To assess the effectiveness of a physical exercise training programme in patients with mild to moderate COPD in the primary care setting, in comparison with usual care. 2) To analyse the main physiological (and behavioural) characteristics of…

Ketanest in Intensive Care Unit Patients

Compare induction of anaesthesia using etomidate versus ketanest on hemodynamics, as well as microcirculatory consequences in patients admitted to the ICU and in need of ventilatory support.

Does reducing pulmonary hyperciculation affect pulmonary capillary permeability in severe ARDS patients? - a pilot study.

To study the effect of reducing the pulmonary circulation to normal levels on the pulmonary leak index in patients suffering from severe ARDS.

Low-flow extra-corporeal CO2 removal and 4 mL/kg tidal volume vs. 6mL/kg tidal volume to enhance protection from ventilator induced lung injury in acute lung injury: a randomized multi-center trial

Lower tidal volumes in order to reduce VILI and days on the ventilator which will reduce the number of days on the ICU

LOw versus COnventional Tidal Volumes during One-lung Ventilation for Minimally Invasive Esophagectomy - A Randomized Controlled Trial

We hypothesize a lung*protective mechanical ventilation using lower tidal volumes during general anesthesia for minimally invasive transthoracic esophagectomy to protect against postoperative pulmonary complications in patients undergoing minimally…