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The metabolomic profile of an embryo as selection criteria for embryo transfer in IVF or ICSI treatment: a randomised controlled clinical trial

The main objective is to study pregnancy rates after using metabolomic profiling added to the selection of viable embryos by morphology, compared to using only morphology.

The magnitude of platelet inhibition and the pharmacokinetics of a 600 mg loading dose of clopidogrel, in different patient categories (stable angina versus acute-coronary syndromes versus ST-elevated myocardial infarction).

The primary aim of this MAPCAT-study is to investigate whether pharmacokinetics of clopidogrel differ significantly betwen different clinical scenarios. A second aim is to study specifically whether genetic polymorfisms influence these…

Psychophysiological stress mechanisms in chronic inflammatory diseases; an experimental study

Referring to the previous CMO approved research proposal (2004/222), in this study the effects of a short-term stressor and a stress-reducing intervention on neuroendocrine, immune and self-reported indicators of stress reactivity in patients with…

Effectiveness caries-preventive measures in children. A non-operative caries treatment programme and fluoride regime: a comparison.

To investigate whether this model, disigned in the Danish region of Bornholm, is applicable in the Dutch situation and can reach comparable results, this study is being repaeted in a regional office for children's dental care in 's…

Multicentered randomized controlled trial to test the cost effectiveness of urodynamics in women with symptoms of stress urinary incontinence in whom surgical treatment is considered.

To test the value of preoperatively performed urodynamics with regard to outcome of surgery for stress urinary incontinence (SUI) and to examine whether not performing urodynamics preoperatively is more cost effective than performing urodynamics…

Endoscopic Tri-Modal Imaging (ETMI) for the detection of early neoplasia in patients with Barrett*s esophagus (BE) in tertiary referral centers; a randomized cross-over multi-center study.

Does ETMI improve the dysplasia in Barrett's esophagus?

The effect of therapeutic horseback riding on balance, spasticity and general well being on patients after stroke / non-congenital brain injuries

This project has been defined to investigate the effect of therapeutic horse riding on balance, spasticity and general wellbeing in 30 adults in the age of 18-80 with physical impairments following a stroke or non-congenital brain injury.

Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure

The primary objective of this study is to evaluate whether treatment with nesiritide improves patient outcomes (as measured by reduction in the composite of HF rehospitalization and all-cause mortality through 30 days after randomization [Day 30])…

Detection and treatment of major depression in patients with somatic illnesses admitted to the general hospital

The aim of the study is to:1. assess the prevalence of depression in patients with somatic illnesses admitted to the general hospital and to examine which self-report questionnaire is most suitable to screen for depression in this setting;2. to…

C-reactive protein assisted prescribing for respiratory tract infections to stimulate Antibiotic stewardship; a randomised controlled trial in general practice

To determine the effect of point of care (PoC) C-reactive protein (CRP) testing and delayed prescribing on antibiotic prescribing for acute lower respiratory tract infections (LRTI) and acute rhinosinusitis in general practice.

Prevention of psychosis with a cognitive behavioural intervention in help-seeking young people with an at risk mental state for developing psychosis

The study aims to reduce the number of transitions into psychosis in a group of people who are in an at risk mental state. This is done with a specialised cognitive behavioural therapy.Other aims are:1) Implementation of screening of all people in…

Een gerandomiseerde placebo gecontroleerde studie naar de toegevoegde waarde van D-cycloserine aan exposure therapie bij pati??nten met een poststraumatische stress stoornis

The present study is aimed at testing the effects of D-cycloserine in addition to exposure treatment sessions in PTSD patients, in a randomized double blind placebo controlled study.

Effect of preoperative pelvic floor physiotherapy versus standard care on incontinence in men undergoing radical laparoscopic prostatectomy

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Design of a randomized controlled trial on the effects of COunseling of mental health problems by Occupational Physicians on Return to Work: the CO-OP-study.

The objective of this study is to assess the effects of treatment by the occupational physician of employees with mental health problems according to the guideline, compared with usual care.

Prospective randomized study of the effect of autologous concentrated thrombocytes versus corticosteroidinjection in lateral epicondylitis.

The objective of this study is to prove that a single injection of PRP in the CEO decreases pain and duration of the condition in patients with chronic lateral epicondylitis compared to injection with lidocaine and corticosteroids.The specific…

Reducing bilirubin-induced neurological dysfunction (BIND) in premature newborns, additional use of bilirubin:albumin ratio in the treatment of hyperbilirubinemia

The research question of this study is whether BIND is reduced using B:A ratios in addition to TSB versus TSB only as indicators for treatment of hyperbilirubinemia in preterm infants.

Complete Echo-endoscopic staging of lung cancer vs mediastinoscopy:
a randomised clinical trial.

To asses wheter minimally invasive echo-endoscopic staging by the combination of EUS-FNA (esophagus) and EBUS-TBNA (bronchi) detects more lymph node metastases compared to conventional surgical staging.