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Insulin-induced microvascular dilatation during a physiological stimulus - Studies in hypertension and obesity.

1 : Will the intake of a liquid meal lead to insulin-induced microvascular dilatation in healthy subjects? 2: Does meal composition (high fat meal vs. high carb meal) play a role in the occurence of insulin-induced microvascular dilatation in…

Effect of Intravenous Administration of Recombinant Human Activated Protein C on Local Inflammation and Coagulation after Bronchial Instillation of House Dust Mite Allergen and Lipopolysaccharide in Asthma Patients

The primary objective is to determine the effect of intravenously administered rhAPC on HDM-LPS induced allergic lung inflammation.

The contribution of the sympathetic nervous system to the anabolic effect of estrogen on bone.

The objective is to study the effect of beta-agonist and beta-antagonist treatment on human bone remodeling.

A clinical study to investigate the effects of remote ischemic preconditioning on cardiac mitochondrial hexokinase in CABG patients

The aim of this clinical study is to investigate whether RIPC induced cardioprotection is associated with an increased amount of mitochondrial HK (mtHK) in the heart.

Relevance of Biomarkers and Clinical Predictors of Outcome in Unselected Population with Febrile Urinary Tract Infection at Primary Care and Emergency Department in a Prospective, Randomized Cohort Trial Comparing Short (7 days) Antibiotic Treatment with Conventional Treatment (14 days)

To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…

The effect of the knock down of gut microbiota by antibiotics on parameters of body weight control and insulin sensitivity

To provide insight in the physiological significance and underlying mechanisms involved in the relation between gut microbiota, energy balance and insulin sensitivity in overweight men with impaired glucose homeostasis

The effects of daily neuromuscular electrical stimulation during short term one-legged knee immobilization on muscle mass in healthy young men

To investigate the effects of 5 days of one legged knee immobilization with or without daily NMES on quadriceps CSA, lean mass and muscle fiber characteristics.

The Effect of Taurine on Morbidity and Mortality in the Elderly Hip Fracture Patient

Our primary objective is the effect of taurine on morbidity and consequent mortality.

Effects of sub chronic oral tryptophan administrations on stress-induced mood and eating behaviour in healthy female volunteers differing in the 5-HTTLPR genotype

1) Examining actual changes in food intake and food preference for different foods following psychosocial laboratory-induced stress;2) Examining the effect of multiple (instead of single) dietary TRP administration on acute stress-induced (negative…

Dissecting the mechanisms of fear formation: a pharmacological study with healthy volunteers

• To elucidate the role of noradrenaline in the mechanisms involved in human memory consolidation• Evaluate the levels of cortisol and 3-methoxy-4-hydroxyphenylglycol in the various points of a memory consolidation window• Define pharmacological…

Effect of Video Interaction Guidance in families with preterm infants.

The project aims to gain more insight in the process of bonding between parents and prenature infants, to validate a screening instrument that can be easily adopted in maternity wards of (general) hospitals to detect parents and children at risk for…

The impact of dietary nitrate ingestion on muscle protein synthesis in elderly type II diabetics

To investigate whether the in vivo postprandial muscle protein synthetic response is augmented when dietary nitrate ingestion precedes protein ingestion in elderly type 2 diabetics.

The role of the gut MIcrobiota in the SyStemic Immune respONse during human endotoxemia

To investigate the role of the gut microbiota in the systemic priming of immune effector cells during human endotoxemia

Effect of a soft rubber bristles interdental cleaner compared to an interdental brushes on dental plaque, gingival bleeding and gingival abrasion in a split- mouth experimental gingivitis model

What is the gingival healing effect of a rubber bristles interdental cleaner compared to an interdental brushes after an 3-week non-brushing period (experimental gingivitis) measured with the Bleeding on Marginal Probing (BOMP) index in a group of…

Effect of Fecal transplant harvested from Bariatric surgery subjects on Lipid and Glucose metabolism in subjects with metabolic syndrome;

To investigate whether single dosis of fecal therapy by infusion of allogeneic (post bariatric surgery donor feces in the bowel) or autologous (own feces) have differential effect on lipid-metabolism-mediated insulin resistance.

Differential Susceptibility to Parenting: Gene-Environment Interactions in Children's Problem and Prosocial Behavior

The objective of this subexperiment is to test the hypotheses of emotional reactivity as underlying mechanism to GxE interactions in the behavior development of children. This hypotheses will be tested within an experiment in which we will look if…

RELATE and PREDICT TRD;A pharmacological and neuroimaging study investigating neurobiological effects of Selective Serotonin Reuptake Inhibitors and Norepinephrine Reuptake inhibitors on dopaminergic reward-learning signals and prediction of clinical (non-) response in Major Depressive Disorder

The proposed study aims to examine: I. whether MDD-patients with a high TRD-level have diminished reward/reinforcement learning, dysfunctional dopaminergic, glutamatergic and/or GABA-ergic neurotransmission (relative to no-TRD patients/controls) II…

The effect of maltitol sweetened chewing gum on the oral microbiology.

What is the effect of the use of a maltitol sweetened chewing gum compared to a gum base and no gum in during a 28 days on the composition of the supragingival plaque microbiome in healthy non dental students *18 years old?

Randomised comparison of two different immunosuppressive regimens on progression of arteriosclerosis in renal transplant patients.
Extension of NOCTX-study: Is progression of arteriosclerosis in ESRD patients inhibited by nocturnal hemodialysis or renal transplantation?

To compare in a prospective randomised way the effect of two different immunosuppressive regimens - mTOR-based regimen or CNI-based regimen - on the progression of coronary artery calcification in renal transplant patients measured at baseline, 1, 2…

Arginine and nitric oxide (NO) metabolism in sepsis: L-Citrulline enteral supplementation for the normalisation of the Arginine-NO metabolism.

Primary Objective: To study stimulating effects of prolonged (8h) enteral L-citrulline supplementation on the normalisation of the Arginine-NO metabolism.Secondary Objective: To study stimulating effects of prolonged (8h) enteral L-citrulline…