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Compensatory reading training for people with homonymous visual field defects

This project aims to determine the effectiveness of two reading interventions: Vistra and Rotated Reading. The effects will be investigated on the level of functions, activities and participation. A nuanced view will be provided as to which training…

A Single Dose, Double-Blind, Parallel Arm, Comparative Pharmacokinetic Study of DRL_AB, US licensed Reference Abatacept (Orencia®) and EU approved Reference (Orencia®), Administered by the Intravenous Route to Male Normal Healthy Volunteers

The sponsor is developing a biological product (DRL_AB) similar to the approved medicine Orencia®. As part of medical-scientific studies to confirm the similarity of the biological products, the Sponsor wants to compare DRL_AB with EU-approved…

A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled
Study to Determine the Efficacy and Safety of BIIB122 in Participants with Parkinson*s Disease

This study has been transitioned to CTIS with ID 2023-505645-12-00 check the CTIS register for the current data. Main objective: To evaluate the efficacy of BIIB122 225 mg compared with placebo.Secondary objective: To evaluate the efficacy, safety…

Effect of a probiotic strain on immune response to influenza vaccination

To investigate the effect of Bifidobacterium lactis CECT 8145 BPL1® on the seroconversion rate after influenza vaccination in healthy adults, compared to placebo treatment.

Endothelial cell loss in pseudophakic patients receiving a Paul glaucoma drainage device with its tube inserted in the anterior versus posterior chamber: a randomized controlled trial

Primary: to determine the loss of corneal endothelial cells after implantation of a Paul GDD with its tube either anterior or posterior of the iris. Secondary: to compare efficacy and safety of both procedures.

A phase 1, randomised, double-blind, placebo-controlled, single ascending dose study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of Ent001 in healthy subjects

In this study we will investigate how safe the new compound Ent001 is and how well it is tolerated when it is used by healthy subjects.We also investigate how quickly and to what extent Ent001 is absorbed, transported, and eliminated from the body (…

Effectiveness of Autonomy Enhancing Therapy in hearing-impaired adults with psychosocial problems and/or mental disorders

The study aims to determine the effectiveness of the application of AET in decreasing self-reported deficits in autonomy-connectedness / self-reported symptoms of anxiety and depression in HI adults.

Personalized Mechanical Ventilation Guided by UltraSound in Patients with Acute Respiratory Distress Syndrome

Comparing different ventilation strategies in focal and non-focal ARDS in invasively ventilated patients admitted to the intensive care unit.

Effectiveness of a Brief Intensive Trauma Treatment for adolescents with (subclinical) PTSD: a multi-center randomized controlled trial

The aim of the study is:1) To test the effectiveness and cost-effectiveness of KIT for adolescents with (s)PTSD and comorbid symptoms. 2) To compare the outcomes from the current study with outcomes we have collected in two previous randomized…

A randomized, double-blind, placebo-controlled, Phase III trial to
evaluate the efficacy and safety of intra-articular injections of
RTX-GRT7039 in adult subjects with pain associated with osteoarthritis of the knee

Primary objective:Demonstrate the analgesic efficacy of intra-articular RTX-GRT7039 compared with placebo.Secondary objective:• Demonstrate the analgesic efficacy of intra-articular RTX-GRT7039 compared with placebo.• Demonstrate the efficacy of…

Bioequivalence of a diabetes specific tube feed with a new carbohydrate source

The objective of the study is to assess whether the postprandial glucose response of the adapted product is equivalent to the postprandial glucose response of the original product.

Drug-Coated Balloons versus Drug-Eluting Stents for Treatment of De-Novo Coronary Artery Lesions in Patients with Stable Coronary Artery Disease - the COATED Trial.

The aim of the study is to investigate the value of DCB treatment of single de-novo coronary artery lesions in patients with stable coronary artery disease, as compared to treatment with DES in a randomized fashion.

Pancreatitis and early omega-3-fatty acid infusion for reduction of organ failure and mortality: a multicenter randomized controlled trial (PLANCTON)

This study has been transitioned to CTIS with ID 2023-505220-57-03 check the CTIS register for the current data. The PLANCTON trial will investigate the effect of early intravenous OM-3 FAs on new onset organ failure and mortality in patients with…

The banded mini gastric bypass trial

The main objective is the %TBWL 5 years after surgery. Secondary objectives include Percentage Excess Weight Loss (%EWL); decrease of comorbidities such as diabetes mellitus (DM), hypertension, and hypercholesterolemia; improvement of quality of…

The effect of virtual reality on anxiety and pain in anterior cruciate ligament reconstruction: a prospective randomized controlled trial

The aim of this study is to determine whether VR used in the pre- and postoperative period after elective orthopedic surgery will decrease pain scores.

A randomized controled trial: the effect of a medical grade honey formulation (L-Mesitran®) on clinical symptoms of recurrent vulvovaginal candidiasis

The primary objective is to investigate the vaginal culture (positive or negative) after the application of a Medical Grade Honey formulation (L-Mesitran ®) in relation to the current standard of care (Fluconazole) 1 month after starting treatment…

EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing cystectomy. The ENHANCE randomized controlled trial.

To study the effectiveness of a multimodal prehabilitation program preceding radical cystectomy in reducing the number and severity of perioperative complications within 90 days, shortening the length of hospitalization and reducing the number of…

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients with Severe Hypertriglyceridemia

This study has been transitioned to CTIS with ID 2024-510696-38-00 check the CTIS register for the current data. Primary objective: To evaluate the efficacy of olezarsen as compared to placebo on the percent change in fasting triglycerides from…

Sirolimus-coated balloon versus drug-eluting stent in native coronary vessels

To observe and evaluate the efficacy, of Magic Touch SCB compared to one of the gold standard treatment for native vessel disease, (everolimus-eluting stent, EES).The main OCT subanalysis endpoints are:- Acute mean and minimum lumen cross-sectional…

Does peRiopErAtive Music prevent sleep disturbances in hospitalizEd suRgical patientS?

To study the effect of music on sleep in surgical patients