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Which treatment works for whom? A comparison of sound-exposure therapies

Primary research questions:1. Does tinnitusspecific- behavioural exposure-treatment (T-BET) decrease tinnitus-related fear, tinnitus-severity and enhance recovery, when compared to a masking-therapy with use of personalised on-ear masking-devices,…

The effect of low-dose radiotherapy on pain in mild osteoarthritis of the hip

The main objective of this prospective randomized study is to examine the effect of low-dose radiotherapy on pain sensation in patients with early OA of the hip. Our hypothesis is that radiotherapy can achieve a pain-reducing effect of at least 20%…

Calcifying tendinitis of the shoulder:
What is the best surgical treatment?

Research proposalTo find out what is the best surgical procedure for patients with conservative therapy resistent calcifying tendinitis of the shoulder. Objectives Our main objective is to compare the three different surgical procedures for the…

Patient Partner Education Program 4 All after Resuscitation

The main goal of the study is to measure the effectiveness of the Patient and Partner Education program 4 all (PPEP4ALL) in patients with hypoxic brain injury and/or their spouse/caregiver.

RAR-CLA and cognition

Daily supplementation of 3.5g RAR-CLA will slow down cognitive decline as compared to placebo

The surplus value of Doppler in Hemorrhoid Artery Ligation procedure.

Standard localized ligations are as feasible as doppler-guided ligations of hemorrhoid arteries.

Seroprotection ten years after fractional dose yellow fever vaccination

Neutralizing antibody titers after fractional dosing of yellow fever vaccine are comparable to standard dose vaccination, ten years after primary vaccination

Clinical trial of dabigatran on airway inflammation and coagulation in severe asthma.

We hypothesize that in patients with severe corticosteroid dependent asthma Dabigatran etexilate will: 1. Reduce airway inflammation; 2. Improve asthma control and pulmonary function; 3. Reduce hypercoagulability in the airways.

Randomized trial on the use of rhEPO
in neonates with Rhesus alloimmunization.

To determine if treatment with rhEPO reduces the need for top-up transfusions in neonates with red cell alloimmunization treated (with or without intrauterine transfusions).

PTSD as a result of chronic interpersonal violence in early childhood; Imaginal Exposure vs Imagery
Rescripting vs Body Focused Rescripting.

Objective of the study: The research aims to 2 new forms of treatment for patients with comorbid PTSD as a result of multiple and repeated abuse in childhood to assess and compare Imaginary Exposure. The expectation is that these new forms of…

Vergelijking tussen algehele anesthesie met en zonder toevoeging van een ruggenprik bij hartoperaties

Thoracic epidural anesthesia with local anesthetics produces intense sympathicolysis and protects the heart against ischemia during off pump coronary artery surgery

An international randomized trial in Locally Advanced Breast Cancer comparing 6 courses of neo-adjuvant doxorubicin and cyclophosphamide plus GM-CSF or G-CSF with a split-course administration of 3 neo-adjuvant and 3 adjuvant cycles including either GM-CSF or G-CSF.

To detect any effect on disease-free survival from treatment with 3 neo-adjuvant and 3 adjuvant chemotherapy cycles (standard treatment) versus 6 neo-adjuvant chemotherapy cycles To study the effect of GM-CSF versus G-CSF on potential effect on…

Closed Reduction vs ORIF vs Non-Operative Study of intra-articular calcaneal fractures.

Percutaneous, ORIF and conservative treated of displaced intra-articular calcaneal fractures have a similar outcome as measured with the AOFAS (American Orthopaedic Foot and Ankle Society) score.

Protein intake in patients with colorectal or lungcancer when receiving a nutritional supplement

a higher protein intake at the end of the first treatment cycle in patients with CRC or NSCLC undergoing first line treatment with chemo-, concurrent chemoradio- or immunotherapy who are receiving two servings of test product daily and who completed…

'Effectiveness of Penfluridol (long acting neuroleptic) as compared to second generation oral neuroleptics (olanzapine and risperidone) in psychotic disorder patients: an open label randomized controlled trial'

We hypothesize that penfluridol as compared to oral second generation neuroleptics (olanzapine and risperidone), will show better compliance (primary outcome) and therefore lower healthcare costs.

Effect of a new synbiotic mixture of short chain galacto-oligosaccharides, long chain fructo-oligosaccharides and Bifidobacterium strain on the gut microbiota of caesarean delivered infants.

The study will investigate the effect of a synbiotic test product compared to a control product on the composition and metabolic activity of the gut microbiota of C-section delivered infants.

The Most Effective Treatment Strategy for Diabetic Macular Edema.

Combined (repeated) laser photocoagulation prolongs time to failure compared to anti-VEGF monotherapy.

A comparison of once daily insulin detemir given pre-breakfast or bedtime, according to need, with bedtime insulin glargine in people with type 2 diabetes characterized by an asymmetric insulin requirement across the day and night.

Insulin detemir, when injected once daily at an individually appropriate time (either before breakfast or at bedtime), provides superior glycaemic control to insulin glargine injected indiscriminately at bedtime in patients that had clearly…

KiVa antibullying program

Does KiVa reduce the level of bullying and victimization in elementary schools?

Assessment of Perinatal Outcome by uSe of Tocolysis in Early Labour: Nifedipine versus placebo in the treatment of preterm premature rupture of membranes.

The aim of the study is to assess whether in women with early PPROM tocolytics improve perinatal outcome.