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Multicenter randomized clinical trial in Patients with Juvenile Idiopathic Arthritis and Methotrexate related side effects: Psychological Behavioural therapy versus switch to MTX parenteral versus standard of care

The aim of this study is to explore the incidence of MTX related gastro-intestinal in a large cohort of JIA patients. Secondly, we want to investigate the effect of psychological behavioural therapy or switch to parenteral MTX dosing to ameliorate…

Transcendental Meditation or Hypnotherapy versus Standard Medical Care for the Treatment of Children with Primary Headaches: a Multi-Centre, Pragmatic, Randomized Clinical Study

The goal of this pragmatic, randomized controlled study is to determine the effectiveness of two relaxation techniques, eg. TM or HT added to the treatment of paediatric primary headaches in comparison to standard medical treatment (SMT). TM or HT…

The influence of electroencephalographic Narcotrend Index*- guidance of propofol administration on recovery from procedural sedation for gastrointestinal endoscopy in paediatric patients

To evaluate the impact of electroencephalographic Narcotrend* Index (NI) monitoring on the speed of emergence and recovery from PPS for PGE.

Prevention of depressive symptoms, anxiety, distress and irrational thoughts among victims of cyberbullying on the Vmbo through an online tailored advice.

The online tailored advice is providing adolescents relevant insight in the negative G-scheme (based on RET). This negative G-scheme leads to inadequate coping strategies. The intervention teaches victims to replace negative irrational beliefs into…

Online help for adolescents with mental health problems: experiment of the implementation and effectevaluation at the preventive Youth Health Care

The primary objective of this study is to modernize the practice of the preventive YHC by adding online help for adolescents with mental health problems as an innovative method of working, additional to the *care as usual*. The test implementation…

Peripheral targeting of inhaled rhDNase for chronic obstructive asthma in childhood.

Primary Objective: To investigate the effect of treatment with nebulized rhDNase on pulmonary function in children with asthma and persistent obstructive pulmonary function.Secondary Objectives: To investigate the effect of treatment with nebulized…

Hypnotherapy for adolescents and adults with inflammatory bowel disease and symptoms compatible with irritable bowel syndrome

To study the effectiveness of gut-directed hypnotherapy in the treatment of IBS-like symptoms in patients with inflammatory bowel disease.

Transfusion Alternatives Pre-operatively in Sickle Cell Disease (TAPS study)
Randomised Controlled Trial

To study whether preoperative transfusion increases or decreases the likelihood of having problems after surgery

PRISMA: Pediatric oncologic Research on Improving Speed, Memory and Attention
THE EFFICACY OF NEUROFEEDBACK TO IMPROVE ATTENTION AND MEMORY IN CHILDHOOD BRAIN TUMOUR SURVIVORS: A DOUBLE BLIND, RANDOMIZED, PLACEBO CONTROLLED TRIAL

The aim of this study is to investigate the efficacy of neurofeedback to improve attention and memory in children that have been treated for a brain tumour. If the neurofeedback proves to be effective, we will strive to implement this training for…

Grip op je dip online (Master your mood online): development and effectiveness

The aim of the project is to further develop and study the effectiveness of the Internet groupcourse Gripop Je Dip Online for young people (16-25 years) with depressive symptoms.Development objective:The eight-session groupcourse will be adapted…

A double blind randomized study on the efficacy of cyclopentolate 1% and cyclopentolate 1% with tropicamide 1% in children

To compare one dose of the short acting tropicamide combined with one dose of the longer acting cyclopentolate (c+t) with a double dose of the longer acting cyclopentolate (c+c). To develop a cycloplegics protocol that garantees optimal refractieve…

Stapled or endloop closure of the appendiceal stump in laparoscopic appendectomy. A multicenter blinded randomised trial

The first objective is to determine whether the routine use of endostaplers for closing the appendiceal stump will lead to a lower incidence of infectious complications (intra-abdominal abscess, wound infection), compared to loop closure. The second…

Randomized study on the effects of patient centred communication in the follow-up of children and adolescents with asthma.

To study the effects of changing consultations by starting with the patients agenda on the enablement of children with asthma and their parents to bring forward their questions, worries, problems and beliefs.

A phase II, double blind, exploratory, parallel-group, placebo-controlled clinical study to assess two dosing regimens of GSK2402968 for efficacy, safety, tolerability and pharmacokinetics in ambulant subjects with Duchenne muscular dystrophy

Primary objective: • To assess the efficacy of 2 different dosing regimens of subcutaneous GSK2402968 administered over 24 weeks in ambulant subjects with DMD.Secondary objectives:• To assess the safety and tolerability of 2 different dosing…

Comparative efficacy and safety of two asparaginase preparations in children with previously untreated acute lymphoblastic leukemia (ALL), a phase III clinical trial

This multicentre phase III study is designed to assess the efficacy and safety of recombinant versus E-Coli derived Aaparaginase from Medac, during treatment of children with newly diagnosed ALL according to the DCOG ALL-10 protocol.Futhermore: To…

Effects of drama therapy on anxiety and mood disorders of adolescents compared to care as usual.

The objectives of the study are:Developing an experimental design to obtain empirical data about the effects of a drama intervention on anxiety and mood disorders of adolescents.

A Phase III, 3-Arm, Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study to Investigate the Impact of Diamyd® on the Progression of Diabetes in Patients Newly Diagnosed with Type 1 Diabetes Mellitus.

The primary objective is to evaluate the efficacy of i) a prime-and-boost regimen with 20 µg Diamyd and ii) a prime-and-boost regimen with 20 µg Diamyd, followed by 2 additional single doses with 20 µg Diamyd, compared to placebo with respect…

A Phase 2/3, Randomized, Double-Blind, Multicenter, Multinational, 4-Arm,
Controlled, Dose-Ranging Study to Evaluate Efficacy and Safety of Teplizumab
(MGA031), a Humanized, FcR Non-Binding, Anti-CD3 Monoclonal Antibody, in
Children and Adults with Recent-Onset Type 1 Diabetes Mellitus

Primary:The primary objective of this study is to assess, relative to placebo, the efficacy, tolerability, andsafety of teplizumab when administered according to 3 different teplizumab dosing regimens insubjects with recent-onset (onset within past…

Effectivity of Neurofeedback in youth with AD(H)D-problems and comorbid disorders: a randomized controlled trial

The objective of the study is to investigate, using a randomized controlled trial, whether a neurofeedback is a effective intervention for youngsters with AD(H)D and comorbid disorders. The objective of neurofeedback is to treat the fundamental…

Preventing mood and anxiety disorders in youth: a multicentre prevention trial in the high risk offspring of depressed and anxious patients

The primary objective is to investigate whether a brief (10+2 sessions) Cognitive Behavioural Therapy (CBT) program can (postpone or) prevent the onset of depression or anxiety disorder in an ultra high risk sample of 8-18 year old children of…