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Voed je beter met diabetes type 2: The effects of personalized dietary guidance to increase the intake of fibre-rich foods on cardiometabolic risk profile in individuals with type 2 diabetes

The primary objective of this study is to investigate the effects of personalized dietary guidance to increase the intake of fibre-rich foods, as recommended in the Dutch dietary guidelines, on cardiometabolic risk profile in individuals who have…

Validation and development of new dichoptic VR-gaming method to treat childhood amblyopia; Vedea Amblyopia Therapy (VAT)

The VAT project is set out to prove that this approach is superior and that the Quality of Life of children with amblyopia might be significantly improved in comparison to occlusion therapy.

A Randomized, Placebo-controlled, Single Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetic Profile of REC-4881 in Healthy Volunteers

In this study we will investigate how safe the new compound REC-4881 is and how well it is tolerated when it is used by healthy participants.We also investigate how quickly and to what extent REC-4881 is absorbed, transported, and eliminated from…

COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events

Primary Objective: To prove that in patients with multivessel coronary disease (MVD) (>= 2 lesions with diameter stenosis >=50%) a PCI revascularization strategy based on revascularisation of all lesions presenting a vulnerable plaques…

Mild induced labour prior to planned caesarean delivery to improve neonatal outcome - a randomized trial (Lacarus)

The primary outcome is the occurrence of neonatal respiratory morbidity within 24 hours after birth. Painful contractions. Progression of labour after stopping OCT. Nonreassuring fetal heart rate pattern during OCT.

A Randomised Open-Label Trial of Early, Very High-Titre Convalescent Plasma Therapy in Clinically Vulnerable Individuals with Mild COVID-19

To determine whether convalescent plasma collected from donors who have recovered from COVID-19 and who have a very high titre of anti-SARS-CoV-2 antibodies reduce the risk of hospitalization or death due to COVID-19 in patients with early symptoms…

Dutch ICH Surgery Trial; minimally invasive endoscopy-guided surgery for spontaneous intracerebral hemorrhage

1. To study whether minimally invasive endoscopy-guided surgery, in addition to standard medical management, for the treatment of spontaneous supratentorial ICH performed within 8 hours of symptom onset, improves functional outcome in comparison…

Cancer aftercare in general practice - A blended lifestyle medicine approach

The primary objective of this research is to gain insight into the short term (6 months) and long term (12 months) effects of the blended care protocol on cancer survivors* lifestyle behaviours. The secondary goal of this research is to gain insight…

The banded mini gastric bypass trial

The main objective is the %TBWL 5 years after surgery. Secondary objectives include Percentage Excess Weight Loss (%EWL); decrease of comorbidities such as diabetes mellitus (DM), hypertension, and hypercholesterolemia; improvement of quality of…

The effect of virtual reality on anxiety and pain in anterior cruciate ligament reconstruction: a prospective randomized controlled trial

The aim of this study is to determine whether VR used in the pre- and postoperative period after elective orthopedic surgery will decrease pain scores.

First-in-human, randomized, double-blind, placebo-controlled, single ascending dose study to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic effects of Apta-1.

Part ATo evaluate the safety and tolerability of single and split intravenous doses of Apta-1 in healthy volunteers.Part BTo evaluate the safety and tolerability of split intravenous doses of Apta-1 after LPS infusion in healthy volunteers.

Effectiveness of a Brief Intensive Trauma Treatment for adolescents with (subclinical) PTSD: a multi-center randomized controlled trial

The aim of the study is:1) To test the effectiveness and cost-effectiveness of KIT for adolescents with (s)PTSD and comorbid symptoms. 2) To compare the outcomes from the current study with outcomes we have collected in two previous randomized…

A randomized, double-blind, placebo-controlled, Phase III trial to
evaluate the efficacy and safety of intra-articular injections of
RTX-GRT7039 in adult subjects with pain associated with osteoarthritis of the knee

Primary objective:Demonstrate the analgesic efficacy of intra-articular RTX-GRT7039 compared with placebo.Secondary objective:• Demonstrate the analgesic efficacy of intra-articular RTX-GRT7039 compared with placebo.• Demonstrate the efficacy of…

Bioequivalence of a diabetes specific tube feed with a new carbohydrate source

The objective of the study is to assess whether the postprandial glucose response of the adapted product is equivalent to the postprandial glucose response of the original product.

Drug-Coated Balloons versus Drug-Eluting Stents for Treatment of De-Novo Coronary Artery Lesions in Patients with Stable Coronary Artery Disease - the COATED Trial.

The aim of the study is to investigate the value of DCB treatment of single de-novo coronary artery lesions in patients with stable coronary artery disease, as compared to treatment with DES in a randomized fashion.

Pancreatitis and early omega-3-fatty acid infusion for reduction of organ failure and mortality: a multicenter randomized controlled trial (PLANCTON)

This study has been transitioned to CTIS with ID 2023-505220-57-03 check the CTIS register for the current data. The PLANCTON trial will investigate the effect of early intravenous OM-3 FAs on new onset organ failure and mortality in patients with…

Prediction of dietary intervention efficacy in mild ulcerative colitis patients based on fecal microbiome signatures

The primary objective is to validate the prediction that prebiotics intervention boosts butyrate production and thereby induces a higher response (lower mean Patient Simple Clinical Colitis Activity Index (P-SCCAI) score) in mild UC patients with…

Pred Forte® in chronic central serous chorioretinopathy

This study has been transitioned to CTIS with ID 2024-511575-15-00 check the CTIS register for the current data. The main objective is the measure the effect on subretinal and intraretinal fluid in severe cCSC calculated by the cumulative areas of…

A randomized, double-blind, placebo-controlled, multiple ascending dose study to evaluate safety, PK and the immunosuppressive effects of p38 MAPK inhibitor POLB 001 on the intradermal and intravenous LPS challenge response in healthy volunteers.

• To evaluate the effect of POLB 001 on inflammatory responses following an intradermal LPS challenge in healthy volunteers• To evaluate the effect of POLB 001 on inflammatory responses following an intravenous LPS challenge in healthy volunteers

Does colchicine reduce progression of aortic valve stenosis?

This study has been transitioned to CTIS with ID 2024-513486-39-00 check the CTIS register for the current data. The main objective of this study is to determine the effect of colchicine on the progression of moderate AS in asymptomatic patients.