61 results
The aim of this study is to prove the efficacy of 3 times daily 1 mg glycopyrronium bromide versus placebo in patients with PD with hypersalivation. Furthermore, the safety of glycopyrronium bromide used in the mentioned dosage will be further…
STUDY OBJECTIVESTo determine whether NAC therapy results in decreased red cell PS exposure, endothelial activation, inflammation, and reduction clotting activation in the steady state.
The aim of this study is to develop a valid and reliable instrument to estimate the extent to which gagging problems will interfere with adequate dental treatment and to evaluate possible progress after psychological treatment of gagging problems.
The objective of this study is to evaluate the concentrations in blood after a single administration of 100 mg TMC125. The various administration formulations will be compared to demonstrate that the formulations can be exchanged. The administration…
The application of CGMS offers novel possibilities to define the impact of different exercise parameters like exercise duration, frequency and intensity on glycemic control in type 2 diabetes patients. In addition we are interested in the impact on…
To study the possible relation between systemic inflammation and oxidative stress and muscle breakdown using pharmacological interventions.
The sequential application of chemotherapy and radionuclide treatment in patients with symptomatic osseous metastasized prostate cancer. Patients with more than one painful osseous metastasis will be randomized between 153Sm-EDTMP or docetaxel 3…
Part 1 of the study has two objectives. Firstly, we will study the safety and tolerability of the drug after the administration of single ascending oral doses of the drug. Secondly we will study the pharmacokinetics and pharmacodynamics. This means…
To determine the association between the development of sensory specific satiety and intensity of oral sensory stimulation. Specifically, the development of SSS after consumption of a bar shaped snack vs. a nibble shaped snack of similar ingredients…
To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…
Objective: To compare the yield of Symptom Association Probability with two approaches to investigate patients with PPI-resistant symptoms: 24-hour pH monitoring off PPI and 24-hour impedance monitoring on PPI.
To study the impact of 3 day exposure to atorvastatin 80mg on Annexin A5 targeting after ischemic exercise in the non-dominant forearm.
To determine the differential effect of age (children vs. adults) on the development of sensory specific satiety (SSS) in relation to intensity of drinks (both sweetness and flavour). To compare two methods of assessing SSS.
To determine the specificity of the effects of histamine H1-receptor blockade on different cognitive functions and processes.
Aim: The aim of the present study was to evaluate the effect of 3 manual toothbrushes with regular and soft filament designs in relation to gingival abrasion and plaque removing efficacy
1. To test feasibility of mannitol inhalations in a Dutch pulmonary out-patient clinic.2. To compare time and costs involved in measuring airways hyperresponsiveness by methacholine to mannitol
The aim of this study is to investigate the efficacy, accuracy and patient satisfaction of intra-articular injections in the osteo-arthritic ankle joint using the traction device compared to the conventional method of injecting.
With intervention with bronchodilators (usual care bronchodilators for COPD subjects), in one study histamine and in one study steroids, we want to investigate the respons on inspiratory lung function parameter like the FIV1 and also investigate…
The primary objective of the present study is to assess the agreement rate of Scintimun® Granulocyte and 99mTc-WBCs with regard to the diagnosis of infection/inflammation by immunoscintigraphy, based on the evaluations of three blinded and…
In this study, the effects of low-fat dairy products on metabolic risk markers in subjects at increased risk of metabolic disorders are determined.