103 results
Primary Objective • To assess the effects of 80mg of furosemide delivered by subcutaneous delivery in the abdominal area over 5 hours when compared to oral administration in patients with heart failure with chronic fluid overload. Secondary…
Main objective: To investigate whether spironolactone can favourably alter extra-cellular matrix remodelling, assessed by changes in the fibrosis biomarker Procollagen Type III N-Terminal Peptide (PIIINP), in patients at increased risk of developing…
The aim of this project is (1) to examine reproducibility of measuring CO and LBF with PC-MRI during supine cycling (phase I) and (2) to measure CO and LBF during supine cycling in patients with CHF and healthy age-matched controls to investigate…
Primary Objective: Evaluation of the benefit of IABP counterpulsation in patients with diuretic-resistant congestive heart failure. Secondary Objective(s): - To lower the burden of disease/improve symptoms, to shorten duration of stay in the…
Objective with respect to patient care: Obese patients have an increased risk of developing heart failure. By gaining insight on the role of obesity in cardiac dysfunction it will be possible to provide a better risk stratification for the onset of…
The primary objective of this study is to identify in what manner micro- and macro hemodynamic parameters responds to critical illness and therapy, and to determine how this interaction is related to different states of organ dysfunction (heart,…
2. STUDY OBJECTIVESSpecific Aim 1. To determine whether Tako-Tsubo cardiomyopathy is associated with hyper reactivity of the neurohormonal and cardiovascular systems. Hypothesis 1: Patients with a clinical history of Tako-Tsubo cardiomyopathy have…
The primary aim of this observational study is to determine the occurrence of (exercise-induced) pulmonary hypertension (sPAP > 40 mmHg) in IIP patients with an elevated V*E/V*CO2 at AT (> 34) assessed during CPET. And, secondly to…
Primary objective: To compare the impact of a single day of prolonged walking exercise on cardiac function and biomarker responses between heart failure patients and their age- and sex-matched controls.Secondary objective: To compare the impact of 1…
To study remodeling patterns of the left and right ventricle in patients with pulmonary arterial hypertension who underwent lung transplantation, using cardiac magnetic resonance imaging.
Employing PPCM patient-derived iPSCs, we aim to test our hypothesis that cardiomyocytes from PPCM patients exhibit (epi)genetically determined differences in protein expression profiles and functional behavior in comparison to those from healthy…
The primary objective of the present study is to demonstrate that maintaining sinus rhythm after ECV for persistent AF in patients with severe chronic heart failure and reduced ejection fraction reduces NT-proBNP levels.
The primary objective is to gain insight into the causative mechanisms of exertional dyspnea in HFPEF. We hypothesize that exercise induced pulmonary hypertension plays a significant role in the development of complaints. The secondary objectives…
The primary objective is to assess the safety of the CardioKinetix Parachute Implant and Delivery System in the partitioning of the left ventricle inpatients with heart failure due to ischemic heart disease.
Primary to assess the tolerability of the compound after single and multiple oral dosesSecondaryto measure the plasma and urine concentrations of the compound and its metabolites after single and multiple oral doses and to characterise its…
Quantify how many frail elderly aged over 65 years with reduced exercise tolerance and/or exercise induced dyspnoea have previously unrecognised COPD and heart failure.Quantify the difference in prevalence of unrecognised COPD and heart failure…
To predict the risk of particular coronary plaques to cause myocardial infarction
Primary Objective: In 2 study groups, patients with COPD and patients with chronic heart failure:• To investigate whether, in comparison to unaided walking, the increase in 6 minute walking distance (6MWD) using a walking bike is greater than the…
The primary objective is to investigate if a salt-reduced diet leads to an increased reward response when exposed to lower salt concentrations in food.
The major research objective is to investigate 1) whether lowering cardiac and muscular lipid content will improve mitochondrial and cellular function in type 2 diabetic patients, and 2) whether this lipid lowering effect also improves uncoupling in…