The primary objective is to investigate if a salt-reduced diet leads to an increased reward response when exposed to lower salt concentrations in food.
ID
Source
Brief title
Condition
- Other condition
- Heart failures
- Vascular hypertensive disorders
Synonym
Health condition
preferentie voor zout
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Brain activity in reward area's
Saltiness preference (subjective ratings)
Secondary outcome
Sensitivity for saltiness, measured by:
-threshold NaCl
-Supra threshold subjective ratings of NaCl in water
Desire-to-eat salty foods (subjective ratings)
Background summary
Worldwide, the daily sodium intake is too high and this leads to an increased
blood pressure and thereby an increased prevelance of cardiovasular disease. A
reduction of sodium in foods results in a decrease in saltiness, which is often
associated with a less palatable taste. In humans, the perception and
preference for salt is learned by experience rather than by physiological
factors. Preference for saltiness can change by repeated exposure, as shown
before. A salt-reduced diet may increase the reward response in the brain when
exposed to low salt concentations in food and may increase the taste
sensitivity to saltiness.
Study objective
The primary objective is to investigate if a salt-reduced diet leads to an
increased reward response when exposed to lower salt concentrations in food.
Study design
An intervention that consists of a 13-week diet of 2 g dietary sodium a day.
The intervention will be compared with a control (normal, their habitual diet).
Intervention
Intervention: 2 g dietary sodium a day during 13 weeks
Control: Normal, habitual, diet
Study burden and risks
Burden participants:
-inclusion questionnaire
-6X taste tests (taste and rate food and salty solutions)
-6X computertask (rate desire-to-eat salty products visually on computer screen)
-6X tongue scraping (non-invasive)
-4X MRI-scan (questionnaires before scanning, 30 minutes in scanner)
(-5 X blood pressure measurements for control group)
(-5 x 24h urine for control group)
The taste tests and computer tasks will take place within the same session and
take app 45 minutes together. MRI-scans are separate and will take 45 minutes.
The time of the burden is76,5 hours in total, spread out over 15 weeks.
This research is non therapeutic to participants.
The risks associated with participation is negligble and the burden is
considered as low.
Bomenweg 2
6703 HD Wageningen
NL
Bomenweg 2
6703 HD Wageningen
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria for the intervention group of the *Salt* study:
- Participation in the Ka/Na-trial
- Willing to participate in the *Salt* study;Inclusion criteria for the control group of the *Salt* study:
- Drop-outs of Ka/Na-trial due to a too low blood pressure (SBP < 130 mm Hg)
Exclusion criteria
Exclusion criteria intervention and control group of the "Salt" study (only for MRI measurements, there are no exclusion criteria for sensory tests):
• Having a contra-indication to MRI scanning:
(claustrophobia, epilepsy, serious physical or mental illnesses, pacemakers and defibrillators, intraorbital or intraocular metallic fragments, difficulties eating and or swallowing)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL39002.081.11 |
| OMON | NL-OMON22606 |