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Tapering antidepressants in pregnancy: A pragmatic multicenter RCT to investigate risk and benefits for mother and child.

The aim of this study is to investigate the effect of guided tapering in early pregnancy as compared to continuation of SSRIs during pregnancy. We will study effects on both mother and child with a pragmatic approach.

Grumpy or depressed? Disentangling normative irritability from early signs of depression among adolescents with cell-phone micro-measures of daily mood swings.

Objective: We would like to differentiate *normative mood swings*. in adolescence from early signs of depression. A comparison between low-risk adolescents and an at risk and a clinically referred sample is needed to detect an unrecognized subsample…

Anterograde amnesia with electroconvulsive therapy; severety and course; a prospective controled cohort study

This study aims at the questions about anterograde amnesia. How often does it occur in patients being treated with bilateral ECT for a depressive disorder, how does anterograde amnesia develop during the treatment course and how does it subside…

A Randomized, Double-Blind, Placebo-Controlled, 2-Period Crossover Study to Evaluate the Effect of Intranasal Esketamine on Cognitive Functioning in Healthy Subjects

To evaluate the effect of intranasal esketamine 84 mg on cognition, and duration of cognitive effects (if present), as assessed using a computerized test battery (Cogstate®).

Effects and Cost-Effectiveness of Pharmacogenetic Screening among Elderly Starters with Antidepressants: A Pragmatic Randomized Controlled Trial

Primary Objective: * To determine the effects of pharmacogenetic screening for CYP2D6 on the time to reach adequate serum drug levels according to the guidelines.Secondary Objective(s): * To determine the effects of pharmacogenetic screening for…

Using patient-derived neurons to investigate the molecular and cellular basis of Major Depressive Disorder

Overall, our primary research goal is to elucidate the underlying molecular and cellular neurobiology of depression. Specifically, this study will focus on the following key objectives:1. My first objective is centered on the major prevailing…

Understanding the Efficacy of Electroconvulsive Therapy in Patients with Unipolar and Bipolar Depression

This study aims to investigate the neurobiological basis underlying the strong antidepressant effect of ECT in patients with unipolar and bipolar depression using MRI. We will also assess a potential neurobiological basis for the cognitive side-…

Cost-effectiveness of a stepped-care program for depression among primary care patients with type 2 diabetes mellitus and/or coronary heart disease and subthreshold depression.

To evaluate the cost-effectiveness of a nurse-led stepped-care program for depression among primary care patients with type 2 diabetes mellitus and/or coronary heart disease and subtresshold depression in comparison with usual care.

Everyday social behaviour and mood in individuals with a family history of depression

This study aims to investigate how serotonin influences social functioning in healthy adults with a first-degree family member diagnosed with MDD. The primary goal is to investigate the effect of an experimental increase in brain serotonin on…

A single dose, 4-way crossover, double-blind, placebo-controlled, randomized study to investigate the effect of JNJ-42847922 on polysomnography (PSG) measures in subjects with major depressive disorder with insomnia who are stably treated with antidepressants.

Primary ObjectiveTo evaluate the effect of JNJ-42847922 on sleep latency (latency to persistent sleep [LPS]) in MDD subjects, stably treated with an SSRI/SNRI, who suffer from insomnia.Secondary Objectives* To investigate the safety, tolerability,…

Probing neuroprotective effects of single session rTMS on subsequent mood and emotional processing

To examine the protective effects of a single session of high frequency rTMS over the left dorsolateral prefrontal cortex on negative mood and motivated attention.

A Double-blind, Randomized, placebo-controlled, 3-way crossover study to eValuate the single dose Effects of Intranasal eSketamine on saFety of on-road driving in healthy subjects(DRiVE SaFe)

The objective of this study is to investigate whether subjects who have taken esketamine, will be able to drive a car as soon as their cognitive function has been restored. The residual effects on driving performance will be compared to placebo.…

Mood, serotonin and social interaction

This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…

Diagnostic Imaging of Affective Disorders using Emotion-processing in non-depressed patients
(DIADE-II).
A neuroimaging study to determine biomarkers to discriminate unipolar and bipolar depression

We aim to (1) improve differential diagnosis of recurrent MDD and BD by investigating biomarkers at a neuropsychological and neurobiological level ; (2) investigate whether affective neuropsychological testing can be used as a diagnosios tool for…

Neuroimaging, Neuropsychological, Quality of life effects and costs of Deep Brain Stimulation in Treatment-refractory patients with Major Depressive Disorder

The study has 3 substudies with each their separate goals:Neuroimaging part:1. To determine the effects of DBS on D2 receptor binding. 2. To determine alterations in cerebral perfusion associated with deep brain stimulation (DBS).Neuropsychological…

Physical and emotional well-being and cognitive functioning: the PREDICT-MR study

We aim to answer the following research questions:Primary:1) Is a history of major depressive disorder associated with smaller volumes of the hippocampus and is this volume reduction disproportionate to the total brain volume?2) Are depression and…

Post MI Depression in the Picture; a fMRI study comparing depression following myocardial infarction and depression in a regular outpatient population

To compare cerebral activity patterns during emotional and cognitive processing among patients with post-MI depression and patients with regular depression.

Neuroimaging of vulnerability for recurrence in major depressive disorder.
A prospective neuroimaging study investigating neurobiological and psychoneuro-endocrinological mechanisms underlying recurrent Major Depressive Disorder and predicting recurrence.

With this research-protocol we aim to investigate six important issues regarding recurrences of MDD-episodes:1. The differences between healthy controls and patients with recurrent MDD-episodes with respect to structural (sMRI) and functional (fMRI…

Quality of life in the postoperative course of bariatric surgery: a role for diabetes?

1) To investigate the impact of keeping/loosing diabetes on quality of life and psychological well-being in a group of (morbidly) obese patients who underwent bariatric surgery, and 2) To explore whether we can predict postoperative quality of life…

The relation between free serotonin in plasma, serotonin in trombocytes and the genotype of the serotonin transporter in carcinoid patients, patients on selective serotonin reuptake inhibitors and healthy controls.

To determine the influence of the serotonin transporter activity on the plasma free serotonin and dopamine amount and the stored amount (in trombocytes) in three different populations (healthy controls, carcinoid patients and patients on medication…