30 results
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
The objective of the study is to study the effect of Teripratide (rhPTH 1-34) on undercarboxylated osteocalcin levels, testosterone concentrations, glucose tolerance and insulin sensitivity in male subjects with primary osteoporosis.
1. The primary objective is to evaluate the characteristics of the distal radial growth plate on MRI (including functional imaging techniques) and on conventional radiographs in young gymnasts with wrist pain, compared to young gymnasts without…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
Part 1: Quantification of individual patient-prosthesis interactions- Determination of the instantaneous effect of prosthetic knees with variable biomechanical properties on the gait pattern of PULAs (Part Ia). - Determination of the influence of…
In this exploratory pilot study, we aim to investigate the role of immune activation in osteoporosis in HIV-infected patients on HAART with proven osteoporosis/ osteopenia in comparison to HIV-infected patients on HAART without osteoporosis/…
To investigate whether bone mineral density is lower in apheresis donors than in blood donors.
Is the radiological, histological and biomechanical condition of bone altered after long term bisphosphonate treatment in bone that is subjected to either compressive of distractive forces.
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
This study investigates to which degree osteoporosis patients taking weekly oral bisfosfonate medication are influenced by by three telephone support calls during the first year after starting this medication.To verify the results of patients` self…
Is DEXA accurate to predict bone loss of the femur before undergoing hip revision arthroplasty and provide a tool for quantification of bone loss of the femur before hip revision arthroplasty? Can DEXA be used to monitor bone remodelling after hip…
The purpose of the study is to investigate whether the cyclodextrin added to the cholecalciferol formulation has an effect on the vitamin D3 availability in the body. Thus, it will be investigated if concentrations of vitamin D3 that are found in…
The aims of the present study are 1) to confirm the high prevalence of dRTA in Sjögren using the urinary acidification test with ammonium chloride, 2) to determine the prevalence of disorders in calcium metabolism in pSS patients with dRTA, 3) to…
The objective of this study is to assess the diagmostic accuracy of microMRI to detect ROD in children with ESRD and metabolic bone disease by oxalosis in patients suffering from oxalosis.
The objective of this study is to investigate whether impaired balance control is (partly) responsible for the increased energy cost of walking in stroke patients and amputees by evaluating the effect of external stabilization and destabilization on…
The objective of the study is to investigate the effect of alfa2-adrenoceptors on bone turnover.
This will be a pilot study that aims to gain insight into the effect of Gaucher disease on bone metabolism. For this purpose we formulated the following research questions:What is the effect of inflammatory factors in the serum of patients with…
To test the surgical feasibility of the less invasive percutaneous pedicle screw instrumentation system for the treatment of children with a so called "hypotonic" scoliosis. Additionally, postoperative pain reduction and a reduced hospital…
To obtain the reproducibility of the standing posture using with Der Wippe, a balancing device, with adjustable holder and acquire the 3D ultrasound of the spine of scoliotic patients
In this study the differences in variability and stability of people walking with and without a limb prosthesis will be investigated. In addition, it will be studied which of the employed outcome measures will discriminate best between both groups.…