603 results
Main objective: 1) To investigate whether BAT activity differs between South Asians and Caucasians.Secondary objectives: 1) To investigate whether sympatic stimulation of BAT differs between South Asians and Caucasians2) To investigate the…
To investigate whether increased aldosterone levels in obese individuals lead to impairment of microvascular function through reduction of NO-availability, and to establish the role of microvasculaire dysfunction in the pathogenesis of salt-…
To investigate if the active product shows a postprandial plasma triglyceride profile different from the control product in healthy adult male volunteers.
The main objective is to assess the efficacy of the closed loop system at the home of the patient. Secondary objectives are to assess the safety of the new prototype while the telemonitoring intensity is being reduced during the trial; to…
- To investigate the biochemical response of ITF2984, defined as a reduction in (random) GH < 1.0 mcg/l and/or normalization of IGF-1.- To investigate the biochemical response of ITF2984, defined as a reduction of GH to no more than 2.5 mcg/l…
The main objectives of this study is to see if changes in the innate immune system can be found in diseases associated with increased risk for atherosclerosis
Primary objective of this study is to assess changes in brain connectivity and activity in the Default Mode and Salience Network (hypothalamus, prefrontal cortex, nucleus accumbens, Ventral Tegmental Area) after different sugars and sweeteners.
First part of study (Phase 1)Aim: To evaluate the efficacy of ileal brake activation, by ingestion of an encapsulated nutrient mixture delivered to the stomach (placebo) or distal small intestine (active) analysed by the amount of food consumed…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
In this study we aim to investigate the presence of CAN in diabetic patients scheduled for elective major abdominal and thoracic surgery and its relation with perioperative hemodynamic changes.
To assess the acute (2h) and short term (2 days and 4 week) effects of daily administration of 5g of NWT03 (an egg-protein hydrolysate) on carotid-radial Pulse Wave Velocity (cr-PWV). Secondary objectives are to assess its effects on carotid-femoral…
To evaluate the difference in the post fat load non HDL after an oral fatload between bezafibrate and placebo in patients with FD using standard lipid-lowering therapy
- To determine whether there is a mitigated immediate immune response to islet infusion in immunosuppressed recipients- To determine if complement activation during immediate immune response is affected in immunocompromised recipients
The current study aims to investigate the effect of a) caloric restriction (very low calorie diet (VLCD)); b) caloric restriction with mechanical restriction and physiological changes through malapsorption (Roux- en- Y bypass (RYGB) surgery); and c…
Brown adipose tissue activity and energy metabolism in cachexia induced by cancer or chronic disease
To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.
Verification of functional tests with the LoRRca, a next generation ektacytometer, on red blood cells of healthy individuals with or without comorbidities/risk factors.
To characterize phenotypical parameters, cytokine production and epigenetic characteristics of monocytes in patients with diabetes mellitus type 2, stratified according to antidiabetic treatment regime. Ex vivo exploration of the conditions which…
To study the pharmacokinetics of non-reactive labelled histidine (L-HISTIDINE:HCL:H2O (D5, 98%; 15N3,98%) and the effect on intestinal imidazole propionate (IP)production in small intestine vs colon in healthy controls, metabolic syndrome and DM2…
Aims of the Study: Our main aim is to characterize cortical brain plasticity in individuals with impaired fasting glucose (IFG) and patients with type II diabetes mellitus (DM2) as compared with age-, gender-, and IQ-matched healthy controls(HC).•…
The aim of this pilot study is to assess the effect of low intensity mastication training in patients with a mitochondrial disease on masticatory performance, efficacy, endurance, bite force and the feasibility of this training .