72 results
To investigate whether sodium and potassium mutations are found in a cohort of patients with small fiber neuropathy, painful diabetic neuropathy (versus diabetes patients with no or only minor symptoms) and in patients with breast, ovarium or…
Primary: To explore the diagnostic value to distinguish PAF and MSA of a variety of tests: corneal confocal microscopy optical coherence tomography (OCT) to measure the retinal nerve fibre layer thickness and total macular volume, corneal…
In the current study we want to further explore the predictability of pre-treatment pain variability on the probability to experience pain relief. Knowledge on the understanding of individual differences in analgesic properties of a drug is of…
The primary objective of this study is to investigate attenuation of pain and sensory thresholds during dorsal root ganglion stimulation using QST. The secondary objectives of this study are to investigate 1) To assess changes in pain intensity (NRS…
PrimaryTo assess the preventative effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model using HPTol upon multiple dosing of GLPG1205 versus placebo.SecondaryTo further assess the preventative effect…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
1.To document natural history in this patient group and to establish which factors put patients at risk for an unfavourable outcome. 2.To determine which factors contribute to (reduced) quality of life (QoL) in patients with MMN.3.To investigate the…
Our primary objective is to study the cellular immune response in CIDP during different stages of disease activity and to explore their role as a biomarker for treatment response and disease activity in patients with CIDP.
To investigate the potential value of magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) on a 3 Tesla and 7 Tesla MRI system and ultrasound (US) to visualize the peripheral nerves and muscles in the forearm to diagnose MMN and ALS…
The primary objective of this investigator initiated project is to determine whether the use of the WalkinSense in the production of new fully customized therapeutic footwear for diabetic patients with a history of foot ulceration results in lower…
At this time, iontophoretic administration of S(+)-ketamine is a already in use as a treatment of peripheral neuropathic pain in several pain clinics In the Netherlands (including the pain clinic at the Medical Center in Alkmaar). Although this…
To develop pulse transit time into a diagnostic device which can be used to assess an altered cold/heat mediated vasomotor response (CHMV) (central component) and the flow-mediated dilatation (FMD) (peripheral component) in CRPS patients.
The goal of this study is to examine the effect of cooling on neuropathy in the hands of patients who are treated with Paclitaxel, Docetaxel en Oxaliplatin. Patients who will be included in the study are those who start with chemotherapy. The…
Primary Objectives• To evaluate the analgesic efficacy of JNJ-42160443 (1, 3, and 10 mg; administered as a single, subcutaneous injection every 28 days) in reducing average pain intensity, in subjects with postherpetic neuralgia neuralgia • To…
The aim of this study is to investigate the possible consequences of generic-generic substitution of gabapentin, a frequently used anti-epileptic drug.
To clarify the aetiology of CTS and prognostic factors for the development of CTS.
Primary objectiveTo determine whether a second IVIg dose in GBS patients with a poor prognosis improves functional outcome after 4 weeks.Secondary objectives To investigate whether: - a second IVIg dose in GBS patients with a poor prognosis improves…
To determine the influence of a pure sensory polyneuropathy on balance correction in light of the first trial response and in light of multiple succesive identical perturbations, compared to healthy control subjects.
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
Primair: To assess the change in the CD11b expression in leukocytes and in plasma concentrations of nociceptin after oral single dose administration of 12 mg GRT6010 compared to placeboSecundair:To assess the difference in area of the capsaicin-…