39 results
The objective of the study is to determine the protein profile of cerebrospinal fluid of non-pregnant women using mass-spectrometry.This study is a follow-up project on the previously performed study (LEPRA, CSF and pre-eclampsia, MEC 2007-087). In…
The aim of this study is to investigate the effect of guided tapering in early pregnancy as compared to continuation of SSRIs during pregnancy. We will study effects on both mother and child with a pragmatic approach.
a. To investigate the phenotype and function of immunological cells present in endometrial and peripheral blood of women with a history of recurrent miscarriages and women without any known pregnancy complications.b. To investigate the association…
The main goal of this study is to establish the reliability (internal consistency and interrater reliability) and validity (discriminant, contruct and predictive validity) of the INCAS. Differences between the SMI and healthy group will be studied (…
The principal aim of this study is to elucidate the role of the glycocalyx in the pathogenesis of pre-eclampsia by assessing: - Whether the glycocalyx is affected in pre-eclampsia and is related to its severity.- Whether glycocalyx perturbation is…
To test The Selection Failure hypothesis by assessing A) the degree of embryo invasiveness and decidual acceptance (the quality of decidualization, endometrium-embryo communication and endometrial stromal cell (ESC) migration) and B) the angiogeneic…
This study aims to test whether non-invasive measures of SNS activity can predict preeclampsia and whether magnesium sulphate in preeclamptic patients reduces the hypersympathetic state. We will quantify SNS activity using the pre-ejection period (…
a. To study whether a specific set of biomarkers is associated with PE with DVb. To study whether a specific set of biomarkers is predictive of PE with DV.
Storage of blood samples, placental material and ultrasonic measurements to be used in a future study the prediction of PE and DV.
Main objective of this pilot study is to compare vascular lesions of the placental bed spiral artery characteristics in pre-eclampsia to spiral artery samples after an uncomplicated pregnancy. Aim of the pilot study will also be to determine the…
To investigate whether SAF is elevated in GDM versus non-diabetic pregnancy To investigate whther SAF levels change during the course of normal and GDM pregnancy To investigate if SAF is related to other parameters of hyperglycemia (HbA1c, self…
The present study has 2 primary objectives: 1: The first aim of the present study is to explore early detection possibilities using plasma hemopexin activity and plasma ATP levels in cohorts of pregnant women in a time course manner (experiment 1).…
The primary objective of this pilot study is to assess the prevalence of visual field defects in formerly eclamptic women. The secondary objective is to compare the vision-related quality of life between formerly eclamptic and normotensive parous…
Primary Objective: The main objective of this study is to analyse the effects of pregnancy on levels and percentages of CD8 cell subsets in peripheral blood both during and after pregnancy.
Our aim is to determine a Pharmacokinetic/Pharmacodynamic (PkPd) based dosing model for nicardipine used for treatment of severe hypertension in preeclamptic patients. The model is based upon determination of maternal, fetal and neonatal plasma…
We aim to determine an association between the presence of complement binding anti-paternal HLA-C antibodies and preeclampsia.
This study is focused on determination of risk factors associated with preeclampsia and intrauterine growth restriction, both develop in early pregnancy. These pregnancy complications are associated with cardiovascular diseases in later life. We…
The overall aim of the study: To assess whether an exercise program can improve insulin sensitivity and fasting plasma glucose levels of women at high risk for gestational diabetes, assuming that this will normalise their risk of gestational…
The primary objective of our study is get more insight in the role of the RAS in preeclampsia. For this purpose concentrations of RAS components in the maternal circulation and amniotic fluid and the expression of RAS genes in the maternal and…
1. To identify associations or an absence of associations between complaints and impaired daily functioning.2. To get an insight in events in pregnancy related to persistant complaints and impairments in daily functioning after pregnancy.