39 results
We hypothesize that formerly pre-eclamptic women have persistently increased angiotensin II sensitivity, sodium sensitivity, insulin resistance and sympathetic nerve activity together initially leading to susceptibility for early renal disease and…
1. To investigate the influence of different immunosuppressive drugs on the immune response of placental derived mononuclear cells, peripheral blood derived mononuclear cells, and cord blood derived mononuclear cells.2. To investigate the neonatal…
The primary objective of this study is to determine the prevalence of white matter lesions and subjective/objective neurocognitive functioning in women several years after pregnancy compared to nulliparous women The secondary objective is to…
Primary ObjectiveDifference in incidence of an avulsion injury and morphological changes of the levator ani muscle after a first normal vaginal delivery between participants with and without a mediolateral episiotomy.Secondary ObjectiveChanges in…
Main objective of this pilot study is to investigate the placental bed histological phenotype and evaluate a scoring system for lesion characteristics of the placental bed spiral artery in pre-eclampsia and uncomplicated pregnancy. The secondary…
To design a multivariate prediction model of pregnancy outcome in women with PCOS with the intention to define intervention strategies for the future.
Disease activity, perianal involvement and lesion localisation are important influential parameters making sure no pregnancy is exactly alike and mode of delivery needs to be considered on an individual patient level.A complete anorectal function…
The goal of this study is to develop and test two tailored intervention programs to stimulate pregnant women to stop drinking alcohol. These intervention programs are a health counseling and a computer tailored intervention. The efficacy of the…
Evaluation of the difference in reporting pelvic floor symptoms when women fill in a standard validated disease-specific questionnaire, without further intervention, compared with daily care, in wich there is no special attention to these complaints…
Primary objectives:• To demonstrate that low ratios of sFlt-1/PlGF predict absence of PE / eclampsia / HELLP (according to diagnostic criteria) within one week after start visit (= Visit 1).• To demonstrate that high ratios of sFlt-1/PlGF predict PE…
To evaluate the effect of CP in the Dutch setting on psychosocial- and health outcomes (concerning the pregnancy) and the success of implementation of CP (including a costanalysis)
Primary Objective: To determine the accumulation of AGEs in the skin and serum of pregnant women with DM1, DM2 or GDM, in comparison to healthy pregnant women and non-pregnant women with DM1 or DM2 and to determine the accumulation of AGEs in the…
To collect maternal blood during the 2nd half of pregnany, in combination with clinical data and data on pregnancy outcome.
To compare the burden for pregnant women and diagnostic capabilities of the oral glucose tolerance test (75g and 50g) and blood glucose samples during the day.
Whether cognitive functions in SGA children are impaired due to inappropriate developmental outgrowth in children born with a low birth weight is unknown. This is also the case for the fact whether GH treatment from the age of 4 years is still…
Primary Objectives: To prospectively investigate the changes in cardiac parameters (echocardiography, NT-pro-BNP) and uteroplacental flow (pulsatility index, diastolic notching) during/after pregnancy in women with CHD and compare these changes with…
The aim of this project is to investigate whether a first trimester model of 3D placental volume, 3D power Doppler measurement of the placental vascularization and/ or serum levels of PAPP-A, PlGF, PP-13, PAI, Ang-2, sFlt and SEng can predict early…
The relationships between emotional complaints of the mothers during pregnancy and the self regulation capacities, temperament, mental and motor development of the children are studied, taking into account the influence of the father, that could be…
The objective of this study is to test the hypothesis that healthy obese pregnant women at increased risk for obesity-related pregnancy complications can be identified by a subgroup-specific screening program at twelve weeks amenorrhea.
Primary objective:To demonstrate elevated numbers of CEC in clinically symptomatic patients with severe preeclampsia.Secondary objectives:- To analyze the relation of CEC levels with organ damage and dysfunction. - To analyze the relation of CEC…