50 results
This study aims to establish a plasmakinetic profile of GABA from tomatoes in healthy men and compare it to the kinetic profile of GABA from a supplement. In addition, the effects of glutamate (precursor of GABA) on the plasma-time curves of GABA…
The purpose of this study is to investigate the effect of recorded music on surgical task performance and mental workload in a simulated setting. The study hypothesis is that preferred music will improve surgical task performance and decrease mental…
A relationship exists between a pharmacologic effect of ENX-201 and the plasma concentration
A newly developed artificial saliva spray (Novospray) alleviates the feeling of a dry mouth in patients suffering from xerostomia better than placebo.
Different processing of milk products will have impact on metabolic availability of amino acid
Overall: when kidney function deteriorates, regulation of the potassium balance in response to potassium loading switches from renal to non-renal mechanisms. 1. Serum potassium in CKD is mainly influenced by alterations in the internal potassium…
Prolonged ingestion of chocolate milk during a training program improves the sports performance parameters in badminton athletes more than control.
Depressive symptom severity is reduced more by active DBS than sham DBS.
This is an exploratory pilot study without specific hypotheses.
Infant formulae with higher levels of milk fat result in improved microbiota composition as compared to standard formula.
It is hypothesized that Ziverel tackles esophageal hypersensitivity by protecting the mucosal barrier function.
After calcitriol treatment, i. resting state striatal neuronal activity, i.e. BOLD signal, is increased and ii. visual food stimuli-induced neuronal activity of brain areas involved in food intake is reduced.
We hypothesize that trimetazidine improves left ventricular diastolic dysfunction in HFpEF, by improving mitochondrial function and increasing myocardial energy content
Patients diagnosed with vasospastic angina (VSA) are at increased risk for cardiovascular events. VSA is characterized by endothelial dysfunction and abnormal vasodilatory reserve. Endothelin (ET)-1 is a potent vasoconstrictor peptide produced by…
With this research we look at the short-term effects of an aronia malanocarpa extract on cognitive functioning in healthy young adults compared to placebo.
* Part A: To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of increasing doses of YTX-7739 in healthy subjects. * Part B: To study the effect of food on pharmacokinetics of YTX-7739 in a selection of subjects who…
The purpose of this study is to investigate how safe modafinil is and how well it is tolerated when it is administered in combination with aniracetam to generally healthy elderly volunteers with subjective cognitive decline. Modafinil and aniracetam…
1) To evaluate the safety and tolerability of MLT*s npMNAs2) To evaluate the pharmacokinetics of intradermal desmopressin administration via MLT*s npMNAs
Primary objective- To evaluate the effects of ACT-541468 on objective simulated driving performance, i.e., the standard deviation of the lateral position (SDLP), after single- and multiple dose administrations (i.e., on Day 1 and Day 4) in the…
The primary objective is to increase sleep quality, and to assess the effect of audio intervention (SmartSleep; Philips Respironics, Murrysville, PA) on deep sleep. Secondary objectives are to improve sleep efficiency, sleep duration, and to reduce…