29 results
Hypothesis: PLS will improve speech understanding in noise in comparison to HiRes, an exisiting state-of-the-art speech coding strategy. The objective is to test this hypothesis. A secondary hypothesis is that PLS improves pitch perception. A…
to investigate the analgesic effect of high frequency 10 Hz rTMS on experimental pain measured through quantitative sensory testing (QST) in healthy subjects.
Primary objective: To evaluate the differences in digestion and absorption on the administration of enteral nutrition either gastric or distal to the ligament of Treitz in the jejunum.Secondary objective: To evaluate the differences in endocrine…
Primary objectives:To confirm the lack of effect of 0.5 mg sublingual testosterone on physiological and subjective measures of sexual arousal in women with HSDD. Secondary objective:To confirm the lack of effect of 0.5 mg sublingual testosterone on…
The objective of the study is to answer the following questions:a) Does the PLS-strategy improve pitch- and speech-perception?b) How does the number of harmonics in consecutive channels influence frequency discrimination, in speech coding strategies…
The primary objective of this study is to evaluate the tolerance of a new smoothie-style paediatric sip feed compared to a standard paediatric sip feed for a period of 6 weeks in children in need of oral nutritional support. The secondary objectives…
Primary:* To determine the efficacy profile of PA101 delivered via a high efficiency nebulizer (eFlow®,PARI) in comparison with placebo following 6 weeks of treatment in patients with indolentsystemic mastocytosis (ISM) who are symptomatic despite…
Provide proof-of-concept for the hypothesis that guanfacine diminishes cognitive side-effects in ER+ BC patients treated with adjuvant hormonal therapy. Secondary, provide data for power calculations in later studies.
To investigate effect of tizanidine ER 12 mg on simulated driving performance, cognitive and psychomotor functions compared with placebo, tizanidine IR 8 mg (two 4 mg doses given 6.5 hours apart) and active-control in healthy subjects
Our main objective is to determine the effect of HO-1 induction by heme arginate infusion on insulin resistance and endothelial dysfunction related to MetS. Secondary objectives are to determine the effect on adipose tissue, adiponectin plasma level…
The objective for this study is twofold. The primary objective of the present study is to assess efficacy of DBS in the nucleus accumbens for patients with refractory MDD. Secondary objectives are the evaluation of long term efficacy and…
Primary objective of this pilot study is to evaluate the in vivo effect of a B2-agonists in CF patients with residual CFTR function, using dosages which are clinically used in patients with asthma. Secondary objective is to evaluate the difference…
- What are the effects of different types of ankle foot orthoses on weight-bearing and static and dynamic balance contribution of the paretic and non-paretic leg in stroke patients? - What are the effects of different types of ankle foot orthoses on…
The sequential application of chemotherapy and radionuclide treatment in patients with symptomatic osseous metastasized prostate cancer. Patients with more than one painful osseous metastasis will be randomized between 153Sm-EDTMP or docetaxel 3…
The primary objective is to examine the effect of body fat distribution on the physiological response to a dietary fat intervention. Physiological response will be evaluated as fatty acid kinetics (plasma and subcutaneous fat appearance), targeted…
The objective of the study is to see whether oral administration of probiotics can modulate certain immunological markers which are associated with accelarated atherosclerosis in patients with ANCA associated vasculitis.
The main objective of this study is to determine whether THC, the primary psychoactive ingredient in cannabis, modulates activity in functional brain systems. We test this by assessing the acute effects of THC on the reward system, the working…
Primary objective:- To evaluate the effect of JZP-110 on driving performanceSecondary objectives:- To evaluate the safety and tolerability of JZP-110- To explore SAFTE (Sleep, Activity, Fatigue, and Task Effectiveness) modeling using driving,…
To explore the effect of single versus repeated preconditioning on circulating blood factors (i.e. metabolomics analysis) as a likely mechanism in patients with cSVD. Secondly, we explore whether the effects of single versus repeated preconditioning…
Primary objective: - To evaluate the effect of the STIL brace on tremor amplitude in patients with forearm tremor. Secondary objectives: - To evaluate the effect of the STIL brace on patients* impressions of tremor severity.- To assess patient…