485 results
We hypothesize that exogenous, enterally provided glutamine contributes substantially to the de novo synthesis of arginine in critically ill patients.
Hypersalivation or sialorrhea is one of the most frequently occuring side effects of clozapine use with an incidence ranging from 30 to 90%. In most cases it occurs at the start of clozapine treatment, mostly at night and persists during further…
The hypothesis is that low dose GC therapy exerts its anti-inflammatory effect by virtue of a first-pass effect through the liver. It is difficult to directly address the hypothesis, but there is an indirect way of doing so: if indeed low dose GCs…
This study aims to establish a plasmakinetic profile of GABA from tomatoes in healthy men and compare it to the kinetic profile of GABA from a supplement. In addition, the effects of glutamate (precursor of GABA) on the plasma-time curves of GABA…
1. Methylphenidate (MPH) increases activation in task relevant areas and task performance 2. Hydrocortisone (HC) increases activation in task relevant areas and task performance 3. MPH + HC increase activation in task relevant areas, but might…
Spinal anesthesia induces several alterations in normal brain processes. Firstly, loss of afferent information increases pain sensitivity. In our previous study on the effects of spinal anesthesia (P11.221) we showed that subjects felt more pain…
We hypothesize that inhalation of helium gas induces release of protective factors in the blood, which can be used to protect different cell types against ischemia/reperfusion injury.
Addition of Partner for Change Outcome Management System (PCOMS) to individual treatment will result in a significant decrease of drop-out compared to individual treatment without PCOMS in a forensic outpatient clinic in the Netherlands. A sub-…
Primary 1. An immediate invasive approach (immediate angiography and revascularization when appropriate) results in a reduction of the combined incidence of death, re-infarction or recurrent ischemia at 30 days follow-up. Secondary 1. An immediate…
We hypoothesize that the effect that a single dose of montelukast has on exercise induced bronchoconstriction correlates with the effect it has after 8 weeks of treatment.
1. TGF-beta protects childhood cancer patients against chemotherapoy induced damage in the digestive tract; 2. TGF-beta can safely be administered to childhood cancer patients.
Electroconvulsive therapy (ECT) is the most effective treatment for severe depressions. Unfortunately, several cognitive side effects with a large pallet of different manifestations and impact often occur. For instance, postictal agitation ((PIA)…
The optimal management of locoregionally advanced NSCLC is evolving. Multimodality treatment is rapidly becoming the most common approach to stage III NSCLC. ASCO guidelines recommend initial chemotherapy (platinum-based, 2 or 3 cycles) combined…
Hypothesis 1: the Groningen ULR and the Provox®2 are the same in terms of the replacement method, the burden on the patient and the convenience of the replacement and of the resistance during phonation. Hypothesis 2: the Groningen ULR has a longer…
Recent pre-clinical experiments demonstrated that sorafenib in Oatp1b2(-/-) mice had 8-fold increased sorafenib-glucuronide blood concentrations.OATP1B1 and 1B3 are highly expressed in the human liver and facilitate the hepatocellular uptake of…
To assess the impact of the physical form of five different cocoa matrices on the bioavailability of the monomeric flavan-3-ols.
We hypothesize that the UC Diet (UCD) can improve induction of remission rates when administered with a 5ASA regimen to pediatric patients with mild-moderate UC vs. 5ASA regimen alone.
Improvement in forearm rotation.
Microalbuminuria in diabetes mellitus is not only associated with progression to renal disease, it is also a potent predictor of cardiovascular disease and thus may reflect widespread vascular damage. Endothelial dysfunction is one of the first…