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An open-label randomised cross-over study to evaluate the albuminuria lowering effect of dapagliflozin, exenatide and their combination in patients with type 2 diabetes

The main objective of the study is to determine the albuminuria lowering effect of the GLP1-RA exenetide, SGLT-2 inhibitor dapagliflozin and their combination in patients with type 2 diabetes and micro- or macroalbuminuria.Secondary objectives are…

The effect of L-arabinose on glycaemic responses in subjects at risk of developing type II diabetes

To examine whether L-arabinose addition to a sucrose drink will lower glycaemic and insulinemic responses in people at increased risk of developing type II diabetes.

The effect of arabinose on sucrose-induced glycemic response and glycemic kinetics as measured by a dual stable isotope methodology

To compare the digestion and absorption kinetics following the ingestion of sucrose plus arabinose versus sucrose only in healthy, young subjects.

Open label, partially randomized, cross-over study to determine the absolute bioavailability
and pharmacokinetics of BAY 1817080 using a simultaneous anticipated therapeutic oral
dose along with an i.v. [13C715N]-labeled microtracer and to investigate the relative
bioavailability of two formulations given under different diets at 2 dose levels in healthy
volunteers.

The main purpose of this study is to investigate how quickly and to what extent BAY 1817080 is absorbed (taken up), distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The pharmacokinetics of BAY…

A Multi-cohort, Randomized Study in Healthy Subjects to Assess the Pharmacokinetics and Safety of Single and Multiple Ascending Doses of JNJ-61393215 (Suspension), and to Assess the Relative Bioavailability, and the Effect of Food on the Pharmacokinetics, of a New Solid Formulation (Capsules) of JNJ-61393215

This study will be performed in 56 healthy volunteers. The study will be performed in 3 parts, Part 1, Part 2 and Part 3. Part 1 will be performed in 16 healthy volunteers divided over 2 groups of 8 volunteers each. The purpose of Part 1 of the…

Building Bridges between Physical Activity and Diet to improve postprandial (cognitive) health

To get insights into how the composition of the meal can affect the effects of prolonged sitting and sitting interrupted with physical activity on cognitive function and other health outcomes.