85 results
This research will have as aim to look at progression or decrease of vascular calcification in dialysis population with use of different phosphate binders. There is a possibility that differect phosphate binders bind vitamin K in a different way in…
The aim of this pilot study is to investigate whether substitution of normal bread by a new palatable form of low salt bread is effective in reducing the daily salt intake in patients with CHF. Furthermore the influence of the presumed salt…
Primary Objective: Evaluation of the benefit of IABP counterpulsation in patients with diuretic-resistant congestive heart failure. Secondary Objective(s): - To lower the burden of disease/improve symptoms, to shorten duration of stay in the…
The objective of this prospective, multi-center, randomized, double-blind trial is to assess the safety and efficacy of the CARILLON Mitral Contour System in treating functional mitral regurgitation (FMR) associated with heart failure, compared to a…
Primary to assess the tolerability of the compound after single and multiple oral dosesSecondaryto measure the plasma and urine concentrations of the compound and its metabolites after single and multiple oral doses and to characterise its…
We will identify factors that interfere with the beneficial effects of exercise on the vasculature in T2DM.
Primary Objective: In 2 study groups, patients with COPD and patients with chronic heart failure:• To investigate whether, in comparison to unaided walking, the increase in 6 minute walking distance (6MWD) using a walking bike is greater than the…
The aim of the study is to measure whether there is a difference in LDL cholesterol levels or the 24 hour ambulatory blood pressure in individuals at high risk of cardiovascular disease when the polypill is taken in the morning compared with the…
To gather data to support global submissions/approvals for some models of the Ingenio device family.
primary objective:-to define the optimal glucose intake by quantifying endogenous glucose production and fractional gluconeogenesis in critically ill children.secundary objectives:-determine glucose utilization in relation with exogenous glucose…
To assess whether dietary nitrate supplementation blunts the ischemia-reperfusion-induced rise in cTnT levels following exercise in type 2 diabetic patients.
The major research objective is to investigate 1) whether lowering cardiac and muscular lipid content will improve mitochondrial and cellular function in type 2 diabetic patients, and 2) whether this lipid lowering effect also improves uncoupling in…
The primary objectives of the study is to test the hypothesis that in healthy volunteers RIPC (bilateral forearm ischemia and reperfusion) reduces troponin I appearance in plasma in response to a high intensive bicycle exercise test.
The primary objective of this study is to evaluate the absolute bioavailability of an oral dose of 10 mg vericiguat (BAY 1021189) given as two 5 mg IR tablets following a high-fat, high calorie meal in comparison to a 14C labeled micro dose of…
This study is designed to objectively document the physiological impact of a micro-catheter on coronary physiology parameters compared with a contemporary 0.014* sensor-equipped guide wire during both basal and hyperaemic conditions, and to identify…
The aim of the current study is to compare the effects of supplementation with concentrated nitrate-rich beetroot juice versus dietary advice to increase dietary nitrate intake through the habitual diet. Therefore, we will assess the impact of 1-wk…
To determine whether addition of selexipag to current PAH therapy improves exercise capacity, imaging parameters and quality of life, delays time-to-first-PAH-related morbidity and mortality, prevents worsening of World Health Organization…
The primary objective of this study is to investigate whether serum taken from volunteers subjected to 30 minutes of helium inhalation can protect different cell types against hypoxia-reperfusion induced damage and to investigate the role of…
To investigate the accuracy of non-fasting lipid profiles versus fasting lipid profiles when lipid lowering therapy is aimed at recommended lipid treatment targets.
Primary Objective • To assess the effects of 80mg of furosemide delivered by subcutaneous delivery in the abdominal area over 5 hours when compared to oral administration in patients with heart failure with chronic fluid overload. Secondary…