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A randomized, double-blind, placebo and reference controlled, multiple ascending dose study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple doses of Memogain administered by intranasal application to healthy elderly subjects.

Objective(s)• To evaluate the safety and tolerability after intranasal administration of ascending multiple doses of Memogain in healthy elderly subjects.• To evaluate the PK after intranasal administration of ascending multiple doses of Memogain in…

A single-center, open-label, randomized, 3-way crossover study to compare the rate and extent of Rivastigmine absorption from two different formulations of 7 day Rivastigmine transdermal systems (7-day RTS) with 24-hour Exelon® patches applied daily for 7 days in healthy male and female subjects.

To compare the rate and extent of rivastigmine absorption from two different formulations of 7-day rivastigmine transdermal systems (7-day RTS) with 24-hour Exelon® patch applied daily for 7 days in healthy adult male and female subjects.To assess…

Effects of a Neurofeedback Treatment on Psychological, Cognitive and Physiological (EEG) outcomes in patients suffering from cognitive decline

So far, only a few case-studies have been tried using neurofeedback in the treatment of dementia / cognitive decline. These indicate that there are behavioural changes and emotional changes next to cognitive changes. This will be the focus of this…

A SINGLE-CENTER, OPEN-LABEL, RANDOMIZED, 3-WAY CROSSOVER STUDY TO COMPARE THE RATE AND EXTENT OF RIVASTIGMINE ABSORPTION FROM A 7 DAY RIVASTIGMINE TRANSDERMAL SYSTEM (7-DAY RTS) WITH AND WITHOUT OVERLAY WITH 24-HR EXELON® PATCH APPLIED DAILY FOR 7 DAYS IN HEALTHY MALE AND FEMALE SUBJECTS

The purpose of the study is to investigate how quickly and to what extent rivastigmine is absorbed and eliminated from the body when administered RTS for 7 days (this is called pharmacokinetics) as well as the safety of RTS.

Neurochemical determinants of fast EEG oscillations

RationaleSince gamma band activity is thought to be an important mechanism in perceptual binding and cognitive function, interest in changes in gamma band activity in neuropsychiatric disorders has grown rapidly. Changes in gamma band oscillations…

Methylphenidate and the pathogenesis of apathy in dementia

The main objective of this project is to study the relationship between dopaminergic mechanisms and apathy in dementia. The related question, both theoretically and of direct relevance for daily practice, is whether patients with dementia are…

The direct effect of cerebral blood flow perturbations on cerebral perfusion and cognitive performance in healthy elderly people

The primary objectives are to study how exercise (i.e. actively performing exercise) affects frontal cortical activation (neurovascular coupling) and the effects on immediate cognitive performance of short periods of reduced and enhanced cerebral…

A Pilot Electroencephalography (EEG) Study to Evaluate the Effect of CT1812 Treatment on Synaptic Activity in Subjects With Mild to Moderate Alzheimer*s Disease

The purpose of this study is to evaluate the safety, tolerability, and effectiveness of the study drug CT1812 in subjects with mild to moderate Alzheimer*s disease. The efficacy of CT1812 will be compared to the efficacy of a placebo. A placebo is a…

Neurostimulation for the treatment of mild cognitive impairment in Parkinson*s disease: an acceptability cross-over study

The primary objective of this study is to assess the acceptability and feasibility of four-week, high-frequency rTMS and anodal high-definition tDCS of the DLPFC as potential intervention methods for the treatment of PD-MCI. Secondary study…

Paracetamol to enhance quality of life and daily function and to decrease care dependency in advanced dementia: A randomized, double-blind, placebo-controlled crossover trial in long-term care facilities.

The overall aim of this study is to achieve optimal QoL and ADL function in long term care falicity (LTCF) residents with moderate to (very) severe dementia and moderate to low QoL, and to achieve less care dependency, less pain, challenging…

The acute effects of sitting and breaking-up sitting on cognitive function in healthy elderly.

The objective of this study is to evaluate the acute effects of sitting on cognitive measures in healthy elderly, and if these effects can be prevented by breaking-up sitting and/or a high mental activity state. In addition, this research explores…

Deep Brain Stimulation of the Nucleus Basalis of Meynert in patients with Parkinson's Disease

The primary objective is to investigate the cognitive effect of low-frequency stimulation of the nucleus basalis of Meynert (NBM) in advanced Parkinson*s disease (PD) patients, who were previously treated with deep brain stimulation (DBS) of the…