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Pain-motor interactions and shoulder pain.

The objective of the study is to find answers on the research question: does activation of descending nociceptive inhibitory mechanisms via central pain medication lead to changes in kinematic and/or muscular changes in shoulder function?

Intra-subject variability in pain scoring and the consequences for analgesia treatment

In the current study we want to further explore the predictability of pre-treatment pain variability on the probability to experience pain relief. Knowledge on the understanding of individual differences in analgesic properties of a drug is of…

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study of CNTO 136 (sirukumab), a Human Anti-IL-6 Monoclonal Antibody, Administered Subcutaneously, in Subjects with Active Rheumatoid Arthritis Despite Anti-TNF-Alpha Therapy

The primary objective is to assess the efficacy of sirukumab as measured by the reduction of the signs and symptoms of RA in subjects with active RA who are refractory to an anti-TNF Alpha agent. The secondary objectives are to assess the following…

effect of the combination of green lipped mussel, curcumin and ribus nigrum (supplement Synofit) on quality of life and pain in patients with osteoarthritis of the knee

measuring the efficicy of the combination of green lipped mussel, curcumin and ribus nigrum (supplement Synofit) on quality of life and pain in patients with osteoarthritis of the knee

A Randomised Placebo-Controlled Double-blinded High Cervical Epidural Neurostimulation Trial in patients with Intractable Cervicogenic Headache

The primary objective in this study is to evaluate effectiveness of optimized high cervical epidural neurostimulation against placebo-stimulation in patients with intractable cervicogenic headache in a neurostimulation trial.

Vitamin D suppletion and aspecific musculo-skeletal disorders

To investigate the effect of suppletion of vitamin D on aspecific musculo-skeletal disorders

The impact of canola protein processing on postprandial plasma amino acid responses in vivo in young females

The goal of this study is to investigate the most optimal way of canola protein processing on blood plasma amino acid responses in young females.

A study to evaluate the sensitivity of muscle velocity recovery cycles to determine changes in muscle excitability, by evaluating pharmacological effects in healthy subjects, and by comparing healthy subjects with myasthenia gravis patients

Primary ObjectivesPart A- To evaluate the sensitivity of muscle velocity recovery cycles (MVRCs) to determine effects of ischemia on muscle membrane potentials- To evaluate the sensitivity of MVRCs to determine effects of mexiletine on muscle…

Central pain sensitisation or (peri)articular damage: the origin of pain in SAPS
A randomised, placebo controlled, blinded, cross-over trial

Our primary objective is to test the hypothesis that there is an association between high CPS at baseline and a low relative effect from subacromial anaesthetics (as compared to subacromial placebo). The increased pain perceived by these patients…

A phase 3, randomized, placebo-controlled, double-blind study of vimseltinib to assess the efficacy and safety in patients with tenosynovial giant cell tumor (MOTION)

This study has been transitioned to CTIS with ID 2024-513624-42-00 check the CTIS register for the current data. Primary Objective: • To evaluate anti-tumor activity of vimseltinib using Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by…