164 results
To measure serum insulin and glucose profiles after bolus insulin administration by a patch-pump versus a catheter based pump, reproducibility of these insulin profiles and the effect of catheter wear-time on these profiles in patients with type 1…
In addition to our current research in type 2 diabetes patients on oral blood glucose lowering medication, we would like to assess the glucoregulatory effects of different exercise modalities in the impaired glucose tolerant (pre-diabetes) state and…
Overall objective:The overall objective is to test the hypothesis that GLP-1 receptor activation of CNS reward and satiety circuits occurs, in the context of food(-related) stimuli, and that this effect is altered in individuals with obesity and…
The effect of NEAT or inactivity on insulin sensitivity and lipid metabolism is unclear. The objective of the present study is to evaluate the effect of 4 days of mainly sitting, or sitting and walking, or sitting, walking and biking on glucose and…
Primary:- to determine the relative bioavailability of a solid formulation (capsule) of PSN821 compared with an oral suspension of the drug.Secondary :- to determine the effect of food on to determine the effect of a high fat meal or light breakfast…
We would like to eludicate the role of dopamine on glucose metabolism.
To investigate the potential beneficial effect of increasing protein in the diet in order to decrease hepatic lipid accumulation on a high-fat diet.
Primary:to assess the glycemic effects of a single dose of OXM on the ambient glucose levels during a GGI assessmentto assess the insulinotropic effects of a single dose of OXM measured as a change in "*" during a GGI assessmentSecondary:…
Pharmacology of rapid-acting insulin injected by needle-free jet-injection in patients with diabetes
To compare the pharmacokinetic and pharmacodynamic profile of the rapid-acting insulin analogue aspart (Novorapid®) injected with jet-injection to that of the same insulin injected with a conventional pen prior to a standardised meal.
Not applicable.
Primary Objectives:1. To compare the magnitude of baseline (or intrinsic) platelet reactivity between T2DM patients and healthy volunteers using multiple platelet function assays 2. To compare the magnitude of baseline (or intrinsic) platelet…
To characterize the glycaemic and insulinaemic responses of regular camel milk and camel milk powder in healthy adults.
For Part A: the purpose of this part is to investigate the effect of multiple oral doses of the new study drug on how quickly and to what extent glimepiride is absorbed and eliminated from the body (this is called pharmacokinetics), if glimepiride…
The objective of this study is to investigate the effect of broccoli seedlings on postprandial inflammatory parameters and insulin sensitivity after an oral glucose load (dual isotope technique) and monitoring the bioavailability and kinetics of SFN…
The purpose of this study is to evaluate the comparative the efficacy of insulin pump therapy versus multiple daily injections in insulin*taking type 2 DM who are sub optimally controlled with MDI.Primary objective: To evaluate between groups change…
To examine whether resveratrol supplementation in type 2 diabetic patients improves overall and muscle-specific insulin sensitivity by affecting mitochondrial fat oxidative capacity. Furthermore, we are interested is this also affects liver and…
Based on our hypothesis that differential availability of SCFA will be beneficial effects on substrate and energymetabolism, the following objectives have been and will be addressed:- In our previous study (METC 11-3-079, NL38679.068.11) we have…
Based on our hypothesis that orally ingested inulin is fermented into different SCFAs, and these SCFAs can have beneficial metabolic effects, we aim to address the following primary objective: To investigate the human metabolic effects of SCFA…
To compare the pharmacokinetic and pharmacodynamic profile of the rapid-acting insulin analogue aspart (Novorapid®) injected subcutaneously by jet-injection to that of the same insulin injected with a conventional pen in the management of…
The effect of different flour compositions in a carbohydrate food product on exogenous and total blood glucose.