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The effects of nanoparticles and ambient particles on brain function using quantitative electro-encephalography (QEEG) in healthy volunteers

To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…

Pharmacokinetics of levetiracetam after rectal administration in healthy volunteers

Comparison of single-dose pharmacokinetics of levetiracetam after rectal versus oral administration at healthy volunteers.

A randomized, open-label, four-way cross-over, single dose study to compare the pharmacokinetics of monomethyl fumarate and other metabolites after administration of dimethyl fumarate as a delayed- and slow-release formulation of FP187 and Tecfidera® in healthy volunteers.

Primary ObjectiveThe primary objective is to investigate the PK of the MMF * the main metabolite of DMF * following administration of a delayed-and slow-release tablet formulation (FP187-GC) and the marketed enteric-coated delayed release…

EFFECTS OF TAPENTADOL ON CHRONIC PAIN AND PARAMETERS OF CENTRAL SENSITIZATION. A PROSPECTIVE, OPEN LABEL, RANDOMIZED CROSS-OVER STUDY WITH PREGABALIN AS COMPARATOR,

The main objective is to determine the change in CS parameters upon administration of tapentadol in comparison to pregabalin in patients suffering from chronic pain that has a visceral or deep somatic origin.

Phase 1 open-label, crossover study to evaluate the effect of food on the pharmacokinetics and safety of a single oral dose of PTC518 in healthy volunteers.

In this study we will investigate what the effect of food is on how the study compound PTC518 is absorbed, transported, and eliminated from the body.We will also investigate how safe the new compound PTC518 is and how well it is tolerated when it is…

A Phase 1, Randomized, Open-Label, Crossover Study to Evaluate Relative Oral Bioavailability of 2 Formulations of PTC857 When Administered as a Single Dose to Healthy Subjects

In this research study we will compare a new PTC857 formulation to the current PTC857 formulation. The aim of the new formulation is to improve ease of manufacturing and to reduce the effect of food on PTC857 uptake. Our aim is to study how quickly…

Hyperbaric Oxygen Therapy Induced Neuroplasticity in Post Stroke Patients Suffering Chronic Neurological Deficiencies

Effect of hyperbaric oxygen therapy (HBOT) on patients with chronic neurological deficiency due to stroke.