78 results
The primary objective of Study I3Y-MC-JPBY (JPBY) is to compare the biological activity ofabemaciclib in combination with anastrozole, abemaciclib monotherapy, and anastrozole monotherapy byassessing the percentage change from the baseline value in…
The objective of this study is to investigate the effect of incongruent and congruent visual feedback on pain reports and Pressure Pain Thresholds (PPTs).
The primary aim of the study is (i) to assess the effect of a soft brace on pain, knee stability and activity limitations. Secondary aims are (ii) to assess the difference in effect of two knee soft braces (i.e., non-tight and tight) on pain and…
The objective of this feasibility study is compare the smart AFO + standardized shoes to subjects* own AFO + own shoes. Subjects* experiences with the orthotic devices will be evaluated and points for improvement will be asked. Subjects* performance…
18-22 YEAR OLD MALES WIHT A NORMAL WEIGHTExamine the possible attenuating cardiometabolic health effects of (A) hourly, 10-min standing interruptions, when compared to a single bout of prolonged sitting, and (B) sitting on a stability ball, when…
Primary Objective: To investigate whether exercise (Diabetes Bootcamp) induces a change in intestinal faecal microbiota (rise of butyrate-producing intestinal microbiota) related to improved glycaemic control (peripheral and hepatic insulin…
To study the influence of systemic blood flow and mean arterial pressure on cerebral blood flow and cerebral tissue oxygenation in patients undergoing on-pump cardiac surgery.
Primary objective: To compare the anti-hypertensive response to dietary salt restriction with the anti-hypertensive response to the diuretics hydrochlorothiazide/amiloride in patients with CKD stages 3 or 4. Secondary objectives: * To analyze the…
Primary objectives:* To explore the comparative bioavailability between 12.5 mg of Risperdal® Consta® prepared from a 25 mg dose strength of Risperdal® Consta® EU-sourced, and 12.5 mg of Risperdal® Consta® prepared from a 12.5 mg dose strength…
Primary Objective: The primary objective is to determine whether the administration of Gelofusine will reduce the kidney uptake of 111In-labeled exendin in humans by enhancing the excretion of 111In-labeled exendin. These highly relevant data can…
The main objective of this study is to evaluate which urine collection method for non-toilet trained children is most suitable for exposure measurement to pesticides with respect tothe burden and convenience, including ease of use, for infants and…
Ticagrelor, at steady state (i.e. after 30 days), will be associated to an improved endothelial function as compared to clopidogrel or prasugrel.
With the current study we aim to assess early brain responses to different food cues (odours and pictures) and we want to determine how these responses are affected by ad libitum intake of product with a specific flavor (sweet/savoury). We expect to…
Primary Objective: Getting insight in the effect of the use of the Genupoint patellar strap on knee joint proprioception in subjects with patellar tendinopathy.Secondary Objective(s): Getting insight in the effect of the use of the Genupoint…
The primary objective is determining whether adding arm propulsion to regular cycling increases total power output. Secondary objectives are determining differences in cycling efficiency, heart rate, muscle activation, maximal oxygen uptake (V02max…
Analyze whether a twice daily regimen is superior to a once daily regime of aspirin when it comes to inhibiting platelet aggregation in cardiovascular patients
The primary objective is to assess changes in endocannabinoid plasma levels prior, during and after eating of hedonically liked versus non-pleasurable foods.
The primary objective of this study is to assess how selective attention to different food characteristics (calories, taste intensity and pleasantness) affects brain responses during tasting. Secondary objectives are to assess (1) whether taste…
Primary objective:•To assess the effect of multiple dose daclatasvir (60mg QD) on the pharmacokinetics (AUC, Cmax, Ctrough, CLr) of multiple dose metformin (1,000mg BID) by intra-subject comparison, in healthy subjects.Secondary objective:•To assess…
Primary objective:To compare the effect of multiple dose atazanavir/cobicistat on the multiple dose phar-macokinetics of daclatasvir with the effect of atazanavir/ritonavir on the multiple dose of daclatasvir by intra-subject comparison in healthy…