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An open-label, randomized, crossover, phase 1 study to evaluate bioequivalence and relative bioavailability between JZP-507 commercial scale and pilot oral solutions in healthy subjects

During the study, an oral solution of JZP-507 produced on a commercial scale will be compared with a JZP-507 oral solution produced on a pilot scale (an oral solution of JZP-507 which is manufactured locally at PRA). The purpose of the study is to…

The Effects of Transcutaneous Vagus Nerve Stimulation on the Pupil Diameter, Heart Rate and Heart Rate Variability in Epilepsy Patients and Healthy Subjects.

Primary objective: The main objective of this pilot study is to gain more insight into the effects of tVNS: to assess if the ABVN and consecutively the NTS are really stimulated by tVNS. Therefore this study investigates the effects of tVNS on the…

The effect of lighting colour and intensity on thermal comfort, physiology & alertness

The objective of the proposed experiments is to study the effect of lighting intensity and spectral composition (correlated colour temperature) on thermal comfort and thermo physiology. The obtained insights can be used to improve thermal comfort,…

Oro-sensory exposure, eating rate and satiation

The primary objective of this study is to determine the independent and additive effects of oro-sensory exposure (mastication effort) and ingestion rate (bite interval) on satiation in relation to the cephalic endocrine and metabolic hormonal…

Double blind, randomized, 2-way cross-over, placebo controlled study to evaluate the therapeutic and preventive effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model in healthy male subjects

PrimaryTo assess the preventative effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model using HPTol upon multiple dosing of GLPG1205 versus placebo.SecondaryTo further assess the preventative effect…

Effects of Modafinil and Caffeine on vigilance in low, medium and high caffeine consumers during the circadian trough in healthy RNLAF aircrew: a randomized controlled trial

To investigate the effect of modafinil (200 mg) and caffeine (300 mg) on vigilance in low, medium and high caffeine consumers during the circadian trough in order to determine the best pharmacological agent to target fatigue.

Acute and delayed effects of MDMA intoxication on false memories in a legal context

Primary Objective: to assess the immediate and delayed effects of THC on true and false memories in a legal context (i.e., on eyewitness and offender statements).Secondary Objective(s): to link drug-induced false memory effects to…

Pilot study into the biomechanical working mechanisms of a brace that aims to prevent hip dislocation after total hip replacement surgery

What is the influence of the Rebound Hip and Newport 4 hip brace on restricting the movements that are associated with hip dislocation after at total hip replacement.

A comparative, open-label, randomized, 2-stage sequential design, 2 periods, crossover study to demonstrate the bioequivalence of 2 FT218 batches (single dose of 4.5 gram) in healthy volunteers

The purpose of the study is to investigate how quickly and to what extent 2 different production batches of FT218 (batch A and batch B) are absorbed and eliminated from the body (this is called pharmacokinetics). In this study it is investigated…

A Phase I, open-label, randomized, two-way crossover study to investigate the effects of morning versus evening repeated dosing on the pharmacokinetics of the combination of GLPG3067, GLPG2222 and GLPG2737 in healthy female subjects.

- To evaluate the pharmacokinetic (PK) profile of the combination of GLPG3067, GLPG2222, and GLPG2737 following repeated morning versus evening doses given to healthy female subjects - To evaluate the safety and tolerability of the combination of…

A randomized, placebo and active comparator (oxycodone)-controlled study on the effect of tapentadol on respiration and analgesia in healthy volunteers

The objective of this study is to investigate the extent of respiratory depression at equi-analgesic dosages of tapentadol and oxycodone

The effect of wheat fiber on increase of fecal bulk

Investigate if an increased consumption of VITACEL Wheat Fiber can enhance fecal bulk. Furthermore, we want to demonstrate that the increased consumption of wheat fiber can increase stool frequency and consistency.

Costs of Implant-supported Over-Dentures (IOD) can be halved using a digital workflow

Our goal is to manufacture a 3D-IOD which is designed digitally, and subsequently 3D-printed. Such 3D-IOD, can be made cheaper, faster and more patient friendly. To prove such a statement, patients should at least be even satisfied about their 3D-…

Effect of total parenteral feeding on the postprandial bile acid response

In this study, we aim to investigate the difference in the anabolic postprandial bile acid response between an enteral and parenteral mixed meal test (MMT) in healthy lean men. This study is important because it may give a better understanding of…

Molecular detection of pulmonary oxygen toxicity using exhaled breath analysis after hyperbaric hyperoxic exposure.

Primary Objective: To study the differences between EB post oxygen-dive, post air-dive (control), dry-dive (recompression chamber) and pre-dive (baseline).1. Will an exposure to a PO2 of 190 kPa (100% oxygen at 9 msw) during 60 minutes in an…

Randomized, double-blind, placebo-controlled oxytocin trial in children with Prader-Willi syndrome.
Effects on social behaviour.

To evaluate the effects of intranasal oxytocin versus placebo on social behaviour and also on eating behaviour in children with PWS.

A randomized, placebo-controlled, double blind, 4-period, cross-over trial, to study blood pressure lowering effects of losartan, Moxonidine and Low sodium diet in former pre-eclamptic women

We hypothesize that formerly pre-eclamptic women have persistently increased angiotensin II sensitivity, sodium sensitivity, insulin resistance and sympathetic nerve activity together initially leading to susceptibility for early renal disease and…

A Phase III Randomized, Placebo-Controlled Trial of Carboplatin and Paclitaxel with or without the PARP Inhibitor Veliparib (ABT-888) in Her-2 Negative Metastatic or Locally Advanced Unresectable BRCA-Associated Breast Cancer

The primary endpoint is to assess the progression-free survival (PFS) of veliparib in combination with carboplatin (C) and paclitaxel (P) compared to placebo with C/P in subjects with a BRCA1 and/or BRCA2 Mutation and HER2-Negative Metastatic or…

The impact of milk protein glycation on plasma amino acid responses in healthy young men

To compare the plasma amino acid responses after the digestion of a milk protein powder with varying levels of protein glycation in healthy young men.

A single-center, randomized, open-label, four-period, four-treatment, cross-over study to investigate the comparative bioavailability of dispersible tablet and capsule formulations of RO5285119 in healthy volunteers

The purpose of the study is to investigate how quickly and to what extent RO5285119 is absorbed from the gut and then eliminated from the body (this is called pharmacokinetics).It will also be investigated to what extent RO5285119 is tolerated.