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Metabolic effects of morning light

To determine the direct effects of morning light intensity on postprandial glucose and lipid metabolism and metabolic gene expression in adipose tissue.

Preservation of metabolic flexibility by acetylcarnitine formation

To test the hypothesis that metabolic inflexibility in pre-diabetic subjects and diabetic patients is due to a reduced capacity to form acetylcarnitines: We aim to investigate whether glucose intolerant subjects have a lower capacity to form acetyl-…

Symptomatic treatment of vascular cognitive impairment

Primary Objective: To study the change on performance on executive function and memory function (as measured on Neurocart), after an active challenge with methylphenidate (monoaminergic) and galantamine (cholinergic), compared to placebo, in…

Effects of deoxycholic acid supplementation on insulin: role for the transmembrane G coupled protein receptor TGR5

To investigate whether postprandial insulin release is affected by administration of the secundary BA DCA

The Role of the Endocannabinoid System in Sweet Taste Intensity and Liking

The primary objective of this study is to assess if cannabinoids modulate sweet taste intensity and liking.

The effects of rectal administration of SCFA on human substrate and energy metabolism

Based on our hypothesis that differential availability of SCFA will be beneficial effects on substrate and energymetabolism, the following objectives have been and will be addressed:- In our previous study (METC 11-3-079, NL38679.068.11) we have…

SCFA production and their metabolic effects after inulin ingestion

Based on our hypothesis that orally ingested inulin is fermented into different SCFAs, and these SCFAs can have beneficial metabolic effects, we aim to address the following primary objective: To investigate the human metabolic effects of SCFA…

Metabolic effects of morning light in obesity and type 2 diabetes

To determine the direct effects of morning light intensity on postprandial glucose and lipid metabolism and metabolic gene expression in adipose tissue in obese subjects with and without type 2 diabetes.

Effects of acute elevation of circulating fatty acids on skeletal muscle lipid accumulation in healthy lean young men

To examine the effect of an exercise-induced elevation of FFA on skeletal muscle lipid content. To this end, we compare skeletal muscle lipid content at baseline and after an exercise protocol and again after a four-hour recovery period from…

The role of bile acids in human brown adipose tissue metabolism

The primary objectives are: 1) to determine the effect of bile acids on glucose uptake in brown adipose tissue; 2) to determine the effect of bile acids on whole body energy expenditure and 3) to determine the effect of bile acids on skeletal muscle…