20 results
Primary 1. An immediate invasive approach (immediate angiography and revascularization when appropriate) results in a reduction of the combined incidence of death, re-infarction or recurrent ischemia at 30 days follow-up. Secondary 1. An immediate…
STUDY OBJECTIVESTo determine whether NAC therapy results in decreased red cell PS exposure, endothelial activation, inflammation, and reduction clotting activation in the steady state.
To test this hypothesis by administering inhaled isotonic magnesium sulphate to patients with stable severe asthma and persistent airflow obstruction (postbronchodilator FEV1 < 75% predicted) and determine the bronchodilating effect by…
The objective of this study is to evaluate the concentrations in blood after a single administration of 100 mg TMC125. The various administration formulations will be compared to demonstrate that the formulations can be exchanged. The administration…
To determine the association between the development of sensory specific satiety and intensity of oral sensory stimulation. Specifically, the development of SSS after consumption of a bar shaped snack vs. a nibble shaped snack of similar ingredients…
To study the impact of 3 day exposure to atorvastatin 80mg on Annexin A5 targeting after ischemic exercise in the non-dominant forearm.
The primary objective of this study is to evaluate the effects of a CYP2D6 inhibitor, paroxetine, on the pharmacokinetics of a single dose of orally administered paliperidone ER. The safety and tolerability of the 3 mg tablet of paliperidone ER…
The aim of the study is to compare the effect jejunal with that of gastric tube feeding on abdominal symptoms.
To determine the differential effect of age (children vs. adults) on the development of sensory specific satiety (SSS) in relation to intensity of drinks (both sweetness and flavour). To compare two methods of assessing SSS.
Aim: The aim of the present study was to evaluate the effect of 3 manual toothbrushes with regular and soft filament designs in relation to gingival abrasion and plaque removing efficacy
1. To test feasibility of mannitol inhalations in a Dutch pulmonary out-patient clinic.2. To compare time and costs involved in measuring airways hyperresponsiveness by methacholine to mannitol
The aim of this study is to investigate the efficacy, accuracy and patient satisfaction of intra-articular injections in the osteo-arthritic ankle joint using the traction device compared to the conventional method of injecting.
With intervention with bronchodilators (usual care bronchodilators for COPD subjects), in one study histamine and in one study steroids, we want to investigate the respons on inspiratory lung function parameter like the FIV1 and also investigate…
To study the possible relation between systemic inflammation and oxidative stress and muscle breakdown using pharmacological interventions.
To determine if adding ammonium to tobacco of cigarettes increases nicotine absorption (amount and speed) in blood of experienced (chronic) smokers.
To estimate the effect of rosiglitazone compared to placebo on ischemia-reperfusion injury as assessed by annexin A5 scintigraphy in the human forearm in subjects with the metabolic syndrome.
Aim: The aim of the present study was to evaluate the effect of 2 manual toothbrushes with different brush head and filament designs in relation to gingival abrasion and plaque removing efficacy
We will investigate the relationship between S(+)-ketamine plasmaconcentrations and its analgesic effect to estimates the onset/offset times of ketamine and potency parameters for various analgesia tests. This will allow the safer administration of…
Cross-transmission of antibiotic-resistant pathogens can be prevented by using closed suction systems (CSS) instead of open suction systems (OSS) in mechanically ventilated ICU patients.
Aim of the present study is to determine · whether and to what extent nadroparin is excreted by CVVH · whether the drug accumulates during CVVH as measured by anti-Xa activity and endogenous thrombine potential (ETP)· whether clearance of nadroparin…