156 results
This study is therefore aimed at quantifying the relative contribution of the two major receptor systhems involved in S(+) ketamine and methadone induced analgesia and side effects( respiratory depression,sedation,miosis).
Sleep (quality and quantity) is beter in ICU patients when they are nursed in a single room compared to nursing in a 'open' ICU.
To quantify the amount of local anaesthetic in blood and tissue fluid in the Bellovac ABT system and in the blood circulation of the patient. The primary objective is to quantify the cumulative ropivacaine level when the blood should be retransfused…
The endocannabinoid system is involved in cognitive functioning, and therefore, challenging this system with THC will influence cognitive processing in humans. Moreover, subjects with cognitive impairments (i.e. psychiatric patients) will react…
We hypothesize that subjects (Asian or Caucasian) with the COMTH allele (Val/Val polymorphism) respond stronger to the GT treatment than subjects with the COMTL allele (Met/Met polymorphism), consequently have an increased EE and that the genetic…
Overfeeding disrupts the hypothalamic response to glucose ingestion in healthy men.
It is hypothesized that in the population of frequent cannabis users, cross tolerance will have developed for the effects of alcohol, and that therefore the behavioral effects after alcohol will be less when given in combination with cannabis.
Genestein inhibits the synthesis of heparan sulphate and can possibly slow down disease progression in Sanfilippo Syndrome patients.
Thiopurine induced hepatotoxicity is related with an enhanced state of oxidative stress and may ameliorate after N-acetylcysteine supplementation.
In the present study we will investigate the efficacy of Lybridos in one group of subjects with FSD in the laboratory. We will measure subjective, physiological and neuropsychological measures of sexual functioning in the Emotional Brain laboratory…
Acute challenges with cocaine and cannabis will induce two opposing dopaminergic states in the brain. Cocaine will stimulate dopamine release leading to hyperdopaminergia whereas cannabis will reduce central dopamine levels resulting in…
Objectives: 1. To investigate the added effects of eplerenone on top of ACEi, with and without dietary sodium restriction, on residual albuminuria, hypertension, and tubular injury markers, in patients with diabetic nephropathy; 2. To investigate…
The main of the study is to gain more information about the sedative effects of two doses (20 and 40 mg) of bilastine and to assess the effect of repeated dosing on the road driving ability. It is expected that no differences will be detected…
Bilateral subthalamic nucleus deep brain stimulation gives rise to local changes in the brain with a subsequent effect on hepatic triglyceride secretion and endogenous glucose production.
While prophylactic use of acetylsalicylic acid and Non Steroidal Anti-Inflammatory Drugs (NSAID’s) is often used concomitantly for long periods of time, there is concern about the safety of this combination in preventing cardiovascular disease.…
Our hypothesis is that alteration of the position of the postprandial acid pocket leads to less acid reflux events. The gastrokinetic properties of azithromycin might enable this effect, as was shown in the study by Mertens et al. {mertens}This…
Dronabinol impairs driving performance in light cannabis users, but not in heavy users, because of tolerance to the impairing effects.
We hypothesize that the electric device offers a more standardized way of embryo transfer, resulting in higher pregnancy rates.
We hypothesize that the hypothalamic neuronal activity in response to water is different in response to a mixed meal.
Deep brain stimulation influences the HPA axis and glucose- and lipid metabolism in patients with obsessive compulsive disorder (OCD).