126 results
In this study we therefore investigate the influence of prednisone on docetaxel exposure in metastatic prostate cancer patients.
To test the hypothesis that the correspondence between orosensation of sweetness and post-oral sensation of calories influences REE, CBF and GE.
The aim of the current study is to compare the effects of supplementation with concentrated nitrate-rich beetroot juice versus dietary advice to increase dietary nitrate intake through the habitual diet. Therefore, we will assess the impact of 1-wk…
The aim of this study is to evaluate the metabolic load during a single session of moderate intensity walking in water compared to walking on land (over-ground) in people with COPD who are normal weight and obese, compared with peak exercise…
The primary objectives are to study how exercise (i.e. actively performing exercise) affects frontal cortical activation (neurovascular coupling) and the effects on immediate cognitive performance of short periods of reduced and enhanced cerebral…
The purpose of the study is to investigate the absorption, distribution and elimination of GLPG1972 administered as oral solution compared to GLPG1972 administered as oral tablets (this is called bioavailability). Furthermore, the effect of food on…
The aim is to test whether EM in EMDR contributes to a reduction in dysfunctional beliefs about recalling the traumatic memory. A sample of Dutch veterans diagnosed with PTSD will be tested. During three EMDR treatment sessions we will measure…
Primary objectiveTo evaluate and compare the single-dose pharmacokinetic of turoctocog alfa pegol from the pivotal process with turoctocog alfa pegol from the commercial process, each given as intravenous administrations of 50 U/kg to patients with…
The primary objective of the study is to evaluate the effect of tiotropium + olodaterol FDCcompared to tiotropium monotherapy on the intensity of breathlessness during the 3min CSST.A secondary objective is to explore the relationship between…
The aim of this pilot study is to see to what extent elderly transfemoral or knee-disarticulated amputees are more independent in their everyday life activities if they use a Kenevo knee joint instead of their current one.
Investigate the effect of administration of CBD by means of CanChew® chewing gum versus a placebo on pain, IBS symptoms and perceived wellbeing in patients with IBS.
The purpose of the study is to investigate how much JZP-258 is absorbed into the body, how fast JZP-258 is absorbed and eliminated from the body (this is called pharmacokinetics) compared to Xyrem. This comparison is called the relative…
During the study, the 4 KEY-507 oral solutions (KEY-507-A, KEY-507-G, KEY-507-C, and KEY 507-D) will be investigated and compared to Xyrem. The purpose of the study is to investigate how quickly and to what extent KEY-507 oral solutions are absorbed…
To determine whether addition of selexipag to current PAH therapy improves exercise capacity, imaging parameters and quality of life, delays time-to-first-PAH-related morbidity and mortality, prevents worsening of World Health Organization…
Examine the effects of a treatment that consists of different natural ingredients on cognitive performance in young healthy subjects. These effects will be compared with caffeine treatment, a natural ingredient that has been found to improve…
• To determine the pharmacokinetics of posaconazole (new solid oral and IV) given as prophylaxis to patients who are at risk for developing fungal infections after receiving conditioning therapy (except strictly non myeloablative (NMA)) for…
Primary ObjectiveTo evaluate the effect of a single 84-mg dose of intranasal esketamine compared to placebo, on next day driving performance and repeated administration of 84 mg intranasal esketamine on same-day driving performance as assessed by…
The aim of this study is to investigate the effects of both dietary nitrate and sucrose ingestion on splanchnic perfusion and intestinal (enterocyte) damage during high intensity exercise.
The purpose of Part A is to investigate how safe the study compound VX-152 is and how well the study compound is tolerated. The study will also investigate how quickly and to what extent the compound is absorbed into and eliminated from the body (…
This project consists of two related studies. The objective of part 1 is to investigate the effect of elevated plasma lactate levels that are sufficient to impair awareness of hypoglycemia on brain lactate concentrations during euglycemia and…