79 results
Serum hepcidin levels are elevated in hemodialysis patients and may contribute to functional iron impairment and thus to ESA-resistance. Kinetics of hepcidin in hemodialysis patients has not been studied in detail. This study is designed to provide…
Primary objective: to compare changes in endothelial function in patients with obesity related hypertension after 8 weeks of treatment with aliskiren, moxonidine and HCTZ.Secondary objectives: to compare changes in the following parameters in…
The objective of this study is to test whether meat structure plays an important role in protein digestion, to maximise the amino acid availability and to stimulate the muscle protein growth in elderly people.
To establish if and how the endocannabinoid system is involved in ADHD and related symptoms. This will be investigated by assessing the acute effects of a cannabinoid agonist (THC) on brain function related to ADHD and ADHD symptoms.
Primary Objectives:1. To compare the magnitude of baseline (or intrinsic) platelet reactivity between T2DM patients and healthy volunteers using multiple platelet function assays 2. To compare the magnitude of baseline (or intrinsic) platelet…
Primary Objective: To determine oral, gastric and duodenal lipid degradation of fat preloads .Secondary Objectives: To study how the oro-gastro-intestinal digestion of these fat preloads relates to: - Colloidal stability. For this we will monitor…
Investigate the effects of levocetirizine, diphenhydramine and placebo on cognitive and psychomotor functioning during controlled simulated diving in a recompression chamber in professional navy divers at 10 mt (2 bar) and 30 mt (4 bar).
The aim of the study is to measure whether there is a difference in LDL cholesterol levels or the 24 hour ambulatory blood pressure in individuals at high risk of cardiovascular disease when the polypill is taken in the morning compared with the…
In this study the effect of SAS and the treatment with CPAP on cognitive functioning, fatigue and mood in stroke patients will be investigated. The main research questions are: 1) Is there a relationship between (the severity of) SAS and cognitive…
Based on the positive effects of Celecoxib on ultrafiltration and peritoneal injury during PD in rats, we would like to propose a pilot study using Celecoxib in PD-patients. In this pilot study we will investigate whether the Cox2 inhibitor…
To gather data to support global submissions/approvals for some models of the Ingenio device family.
At this time, iontophoretic administration of S(+)-ketamine is a already in use as a treatment of peripheral neuropathic pain in several pain clinics In the Netherlands (including the pain clinic at the Medical Center in Alkmaar). Although this…
We will identify factors that interfere with the beneficial effects of exercise on the vasculature in T2DM.
Analyze the protective effect of levocetirizine (LEV), through the direct antagonism of airway H1 receptors and the inhibition of the release or production of other inflammatory mediators, against exercise induced airway obstruction.
The goal of the current investigation is to test a new model that accounts better for results of pharmacological research. This model states that the cholinergic system underlies disengagement, and that the noradrenergic system underlies bias. Two…
The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects <60 kg with stable coronary artery disease (CAD) versus the…
This study is therefore aimed at quantifying the relative contribution of the two major receptor systems involved in S(+)-ketamine and methadone induced analgesia and side effects (respiratory depression, sedation, miosis).
: The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects >=75 years of age with stable coronary artery disease (CAD)…
The objective of the study is to investigate whether the Out-Of-Office BPM device of Microlife, the WatchBP O3, is comparable to the Spacelabs 90217 device at 24h BP measurement. Secondary objectives: To investigate whether the implemented features…
1) To assess insulin sensitivity and response in critically ill septic neonates and children. 2) To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or…