1361 results
Comparing the metabolic response (oxygenuptake and ventilation) and symptom perception (borgscores for dyspnoea and fatigue) between neuromuscular electrical stimulation with low-frequency and high-frequency.
The aim of the study is to compare magnesiumhydroxide and polyethylene glycol/electrolytes with regard to the prevention of constipation and side-effects in palliative care cancer patients starting with opioids.
The primary objective of this study is to determine the effects of aliskiren, as compared to ramipril, on renal hemodynamics in overweight/obese and hypertensive patients.
To obtain more information about the effects of capsaicin and cinnamaldehyde on the intestine, these substances will be infused directly in the duodenum. Hereafter, the permeability of the intestine, gallbladder motility and the effects on satiety…
Our primary objective is to provide a model which accounts for the inconsistencies in the pharmacological literature regarding the role of the noradrenergic and cholinergic system in visuo-spatial attention. Recently we started a University Medical…
To establish the pharmacokinetic profiles of saliva and plasma concentration of 10 mg MPH-IR and 18 mg MPH-OROS in healthy volunteers; to investigate whether there is a correlation between saliva- and plasma levels of MPH-IR and MPH-OROS, and if…
Objective of the study is to test the effects of two different interventions during the nightshift on alertness and performance and on sleep quality and health complaints in general. The interventions are short exposure to light or taking a powernap…
Main objective is to investigate if low molecular weight fraction of edible mushroom Shiitake extract possesses clinically relevant caries preventive properties
The aim of this study is to determine whether subcutaneous administration of insulin detemir, as compared to NPH insulin, leads to a more pronounced effect on brain glucose metabolism and blood flow in brain regions associated with appetite…
Primary:- to evaluate the safety and tolerability of the compound in different multiple dosing regimens in healthy subjects in different dosing regimensSecondary:- to characterize the pharmacokinetics of multiple oral doses of LY2878735 administered…
Primary:Part I:- to determine the effects of gabapentin and remifentanil on the evoked area of hyperalgesia, area of allodynia, pinprick hyperalgesia and background pain using a newly developed HCW sensitization modelPart II: - to determine…
In this study we will be looking at the effects of the different administration routes on release of satiety hormones by the small intestine.
The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects <60 kg with stable coronary artery disease (CAD) versus the…
Part A:To evaluate the safety and tolerability of increasing doses of VX-770 up to 450 mg (q12h) in healthy male subjects.Part B:To determine if therapeutic or supratherapeutic systemic exposure to multiple doses of VX 770 prolongs the mean…
The primary objective is to assess the extent to which sensory properties of products predict satiation, and to investigate whether expected satiation may change after repeated consumption of the product.
The main aim is to develop an intervention to change knowledge, communication and attitudes regarding renal replacement therapy (RRT). The second main aim is to investigate whether this intervention has an impact on the proportion of patients…
The main aim of this study is to collect normative data on the RANDI for several age groups.
Primary: * To determine the effect of food on the bioavailability of E7050 following oral administration of a tablet containing 100 mg E7050 with and without a standard low- or high-fat breakfast (Part A)* To characterize E7050 pharmacokinetics…
The purpose of this study is to test the acute effects of a TRP enriched meal in a dose-dependent manner in MS patients. The results of MS patients without mood disturbances (control group) will be compared to MS patients with mood disturbances (…
Primary objective:•To compare the pharmacokinetic (PK) profiles of gemcitabine-5*-elaidate (parent compound) of two formulations of CO-1.01 in order to investigate whether the confidence interval (CI) for the ratio of the AUC0-* of the two…