127 results
The hypothesis is that low dose GC therapy exerts its anti-inflammatory effect by virtue of a first-pass effect through the liver. It is difficult to directly address the hypothesis, but there is an indirect way of doing so: if indeed low dose GCs…
This study aims to establish a plasmakinetic profile of GABA from tomatoes in healthy men and compare it to the kinetic profile of GABA from a supplement. In addition, the effects of glutamate (precursor of GABA) on the plasma-time curves of GABA…
Appropriate use and prescription of a lower limb prosthesis for people with leg amputation through or above the knee, can increase the efficiency of the integrated care around the leg prosthesis.
We hypothesize that TIPS placement has an significant effect on drug metabolism and bile acid metabolism.
There is a minimal interaction between edoxaban and tamoxifen and it can safely be used concomitantly
In the current study, we will construct utility functions of two opioids, tapentadol and oxycodone, to assess the benefit/harm ratio of these drugs. To that end we will perform a PK PD study in healthy volunteers
1. Serum potassium in hemodialysis patients (CKD stage 5D) is mainly influenced by alterations in the internal potassium balance. 2. Higher dialysate potassium in CKD-5D increases the potassium erythrocyte concentration as proxy for TBK. 3. The…
Patients prefer naratriptan over paracetamol 1000 mg for the acute treatment of migraine attacks.
The purpose of this study is to investigate the effect of recorded music on surgical task performance and mental workload in a simulated setting. The study hypothesis is that preferred music will improve surgical task performance and decrease mental…
A relationship exists between a pharmacologic effect of ENX-201 and the plasma concentration
We hypothese that the health care for hand prosthesis users can be improved in terms of cost-effectiveness.
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
A newly developed artificial saliva spray (Novospray) alleviates the feeling of a dry mouth in patients suffering from xerostomia better than placebo.
Different processing of milk products will have impact on metabolic availability of amino acid
Overall: when kidney function deteriorates, regulation of the potassium balance in response to potassium loading switches from renal to non-renal mechanisms. 1. Serum potassium in CKD is mainly influenced by alterations in the internal potassium…
we hypothesize that thermal comfort and sensation will stay within similar ranges in both conditions (based on a previous study);
Prolonged ingestion of chocolate milk during a training program improves the sports performance parameters in badminton athletes more than control.
Depressive symptom severity is reduced more by active DBS than sham DBS.
After absorption tamoxifen is metabolized by CYP3A4 and CYP2D6 in several (active) metabolites of which endoxifen is the most important.(11) Tamoxifen, like many anti-cancer drugs, relies on phase II metabolism before they can be excreted from the…
This is an exploratory pilot study without specific hypotheses.