65 results
To compare the efficacy of alitretinoin and azathioprine in the treatment of severe chronic non-hyperkeratotic hand eczema.
To investigate the acceptability and feasibility of exercise therapy in an aquatic environment by patients after burn injury.
Objective: We want to extend our understanding of the disease aetiology by performing a small pilot study that incorporates other immunologic sites involved in the disease (the skin and the microbiome) while additionally strengthening our disease…
Primary objective: To prospectively evaluate the lesion (AN-)count, i.e. abscesses, inflammatory nodules, and draining sinuses, in the axilla treated with MWA compared to the untreated contralateral axilla after six months.Secondary objectives: - To…
The main objective of our study is to examine whether there is an association between IT (as determined by visual irritation grading scale after SLS patch test) and HTS formation and whether IT is a good predictor for HTS formation. If so then this…
To determine the relationship between phenotypic, genetic and biochemical features of AD. , Relevant bimarkers of the skin barrier function including the levels of NMFs, inflammatory mediators (e.g. IL-1 cytokines), SC lipids and serine proteases…
To test the suitability of OCT for in vivo imaging of the vascularisation and surrounding tissue of burn wounds and scars.
The primary objective of this study is to detect significant difference in the average response to histamine, topically and iontophoretically applied to the skin, between sensitive and non-sensitive skin volunteers. Skin reactions are assessed with…
The primary objective of this study is to assess the analgesic effect of fractional carbon dioxide laser assisted delivery of two topical anesthetics (articaine hydrochloride 40 mg/ml and epinephrine 10 µg/ml solution (AHES) and eutectic mixture of…
In this project we would like to answer the following questions: To what extent are increased micro-vessel density (MVD) and excessive angiogenesis in inflammatory skin diseases observed during different phases of the disease (i.e. acute/…
We hypothesize that the long lasting therapeutic effect of coal tar could be mediated by effects on the skin microbiome and/or effects on cellular memory by epigenetic changes. In atopic dermatitis patients, coal tar therapy could modify the skin…
to investigate whether the levels of a panel of biomarkers in dried blood spots can be used as a disease severity measurement tool in patients with AD, treated with topical steroids.
By means of this in vivo study, we try to non-invasively get insights into the pharmacokinetics of PPD applied to the human skin. By studying penetration rate, penetration depth, allocation to different skin departments (stratum corneum, epidermis,…
Setup method for detection of STAT3 phosphorylation in human blood derived from patients with various chronic inflammatory diseases.Test the effect of new compounds on this phosphorylation process.
ObjectiveEvaluation of the application of cultured autologous keratinocytes in combination with a meshed split skin autograft to improve burn wound healing
In the present project we would like to find out whether we can observe Treg into Th17 conversion in lesional skin and in the peripheral blood of patients with AD and compare the results to our findings in psoriatic patients and healthy controls.…
In this project we would like to find out whether Sellotape stripped healthy skin can be used as an in vivo model for mechanical skin damage. This would contribute to more knowledge about growth, differentiation, inflammation and mechanical…
To perform a comprehensive analysis of the cellular infiltrate in lesional AD skin, using state of the art immunohistochemical techniques.
Primary objectivesTo study the relation between the physiological, microbiological and immunological status of the skin and the response to an external stimulus; to assess:• the relations between microbiome and/or immunology and the skin type;• the…
The aim is to validate the hypothesis that a positive history defined as dermatitis at exposure to a scented product and thereafter avoidance of such products in fragrance-hypersensitive individuals and a positive patch test result to fragrances is…