22 results
Investigation of pelvic blood circulation by MRI in women with a gynaecological cancer who will have curative radiotherapy with or without weekly HT for inoperable pelvic tumours.
The aim of this study is to investigate to what extent biomarkers are related to the development of ventricular arrhythmias, in order to improve the indication for ICD therapy.
Primary Objectives- To evaluate disease-related characteristics and biomarkers in patients with CLE compared to healthy volunteers. Secondary Objectives- To evaluate the variability of the selected biomarkers between patients - To investigate the…
Objective: The aim of the present study is to study the effect of increased adrenaline levels on the inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by administering exogenous adrenaline. Secondary aims consist of…
The primary objective of the current study is to investigate whether self-disgust is heightened in patients with AN. If this indeed is the case, this would provide important leads to improve existing treatment options for AN.
In this study, we therefore aim to investigate how trained immunity is systemically regulated in ANCA vasculitis patients and how the degree of trained immunity affects disease activity and severity. A better understanding of these processes…
The aim is to investigate changes in nocturnal and postprandial glucose and glycogen metabolism in individuals with IFG and IGT when compared to healthy, non-diabetic, overweight participants. In addition, it will be investigated if reducing…
In the current study, the feasibility, acceptability and effectivity of a new add-on early intervention program for individuals at risk for the development of bipolar disorder is evaluated. This intervention program entails psycho-education, light…
The objective of the study is to investigate the feasibilty, acceptabilty, implementation and preliminary (cost-)effectiveness of the intervention on recovery, health and lifestyle variables.
Primary objectives:To evaluate the pathogen host interactions between S. aureus and NS patients:o IgG and IgG4 responses against S. aureus antigens in NS patients will be compared with IgG and IgG4 responses against antigens of other bacteria (e.g.…
Main objectives: 1. Determine whether the POAG patients with low values of the blood mtDNA copy number have a low mtDNA copy number and low mitochondrial function in skin fibroblasts, using in vitro assays of mitochondrial function.2. Explore the…
Identification, segregation analysis, and functional characterization of genetic variants possibly causing rare bleeding disorders. The following questions will be answered:1) Can we identify (new) causal variants that explain the phenotype of…
This study has the following study aims: 1) Investigate whether treatment context and the addition of chronotherapeutic and social rhythm interventions improve the efficacy of BLT, 2) examine the role of circadian phase resetting and changes in…
Primary Objective: For the primary objective, the following research question is answered: Does performing asleep thalamic DBS provide an equal reduction in tremor compared to awake thalamic DBS, measured by the Essential Tremor Rating Assessment…
The aim of this this study, is to test whether EMDR therapy, relative to a baseline phase, results in: 1) less social anxiety symptoms, and 2) less social avoidance symptoms
In this study, therefore, we aim to investigate how trained immunity is systemically regulated in SLE patients and how the degree of trained immunity affects disease activity and severity. A better understanding of these processes contributes to the…
We aim to collect skin and blood cells from two to three WitKoS patients, reprogram these cells into iPSCs and use the iPSCs for differentiation into neurons/neural organoids to study the molecular underpinnings of WitKoS.
1. To investigate whether the TIMELY intervention is superior to usual care in terms of A) reducing the CoroPredict risk score (indicating risk of 10-year mortality: primary biomedical outcome) from baseline to six months; andB) increasing…
The main objective of this proposal is to establish ex-vivo models of bronchial epithelial cells from children. Use of (1) epithelial organoid cultures derived from bronchial or nasal epithelial cells; and of (2) bronchial brushings; (3) nasal…
The primary objective is to determine whether iRVF patterns and renal damage/function are different in patients with a Fontan circulation compared to age and sex-matched healthy controls.The secondary objectives are to- Identify the prevalence of…