35 results
The overall aim of the current study is to improve quality of life in patients with cognitive disorders. First, by improving diagnosis of PTSD symptoms in these patients. Second, we will estimate comorbidity rate of PTSD in clinical populations of…
Determine the frequency, phenotype and function of disorder-related immune cells, or levels of immune molecules in skin and peripheral blood of patients with inflammatory skin diseases, during the active phase of disease prior to and/or at any time…
Primary: Is OIT with standard food products safe to perform in children aged 9 to 24 months with a proven food allergy for hen's egg, peanut, cow's milk, cashewnut, hazelnut, walnut and/or one of the more rare allergens (as soy, pits and…
The primary objective of the second part of the study, which is the focus of this application, is to perform a comparative analysis of the cognitive profile and MRI outcomes of DMD/BMD patients.
The study aims to determine the feasibility and diagnostic accuracy of quantitative Magnetic Resonance Imaging (MRI) techniques for determining the presence of portal hypertension in patients with severe liver disease. The secondary objectives are…
To assess whether adjuvant chemotherapy can be safely omitted in patients with pathological stage I (pT1a/b/cN0) TNBC and a high sTIL score (defined as >=50% for patients <40 years at the time of TNBC diagnosis; >=75% for…
2.1 Primary Objectives• To identify brain activation evoked by sensation in response to bladder filling in patients with an implanted sacral neurostimulator as a treatment for overactive bladder (OAB), compared to a baseline in OAB patients without…
The current study aims to obtain a better understanding of glymphatic dysfunction in dementia of the Alzheimer*s type and its preclinical stages.The main objective of this study is to improve our understanding of the potential link between…
To determine which biological processes play an essential role in immune-pathological changes in vitiligo skin depigmentation.
The primary objective of the study is to assess the longitudinal effects of differences and changes in renal function at CKD stage 3-5 on physical functioning. The secondary objectives of the study are to assess the longitudinal effects of…
Our primary objectives are to analyse the gene expression profile of non-lesional and lesional skin of patients with NS (ichthyosis linearis circumflexa (ILC) phenotype and scaly erythroderma (SE) phenotype) using single cell RNA sequencing and…
Our primary objective of the feasibility study is to assess the acceptability and feasibility of the developed 2EAT dietary treatment in older adults with obesity. The primary objective the main study (RCT) is to investigate whether a shift towards…
Our study uses a two-step approach. In the first step (study part 1), we will assess the feasibility of the ADJUST-AFO to measure the optimization parameter, walking energy cost, while changing the stiffness during 20 minutes walking in healthy…
Objective: In this study we propose elucidating the pharmacokinetics of olanzapine in AN patients, to optimize the dosing strategy, to the extent of increasing the efficacy and reducing the risk of side effects. To this end, we will assess the…
Primary objective: To evaluate the role of existing and novel quantitative biomarkers in understanding the heterogeneity in the Parkinson*s phenotype (i.e. rate of progression, cognitive and neuropsychiatric impairment and motor dysfunction) and…
The main objective of this project is to build a comprehensive model for a better predictio n of progression in MS, as a first step to move towards personalized prediction. Secondary objectives aim to study specific aspects of underlying mechanisms…
The aim of the 100-plus Study is to identify moleculair and environmental constellations that maintain cognitive healthduring extreme aging.
We aim to perform an in-depth investigation into the role of the mucosal immune response in the pathogenesis of rheumatoid arthritis. Our objectives are to study the presence of RA-specific autoantibodies and several other biomarkers (cytokines,…
To study anti-SARS-CoV-2 antibody-mediated inflammatory responses by macrophages in individuals with obesity.
Why wait? (Cost)effectiveness of an online transdiagnostic therapy for patients and their loved ones
In the current study, we will analyze the (cost)effectiveness of an online, transdiagnostic positive psychology eHealth intervention for patients waiting for psychological out-patient treatment and their relatives. We expect that this intervention…