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The peritoneal microvascular endothelial glycocalyx in peritoneal dialysis patients

The aim of the study is to investigate the changes in peritoneal endothelial glycocalyx in end-stage renal disease (ESRD), with the duration of peritoneal dialysis, and relate these changes to alterations in peritoneal transport and morphology.…

Changes in salt perception as a result of a long-term salt reduced diet

The primary objective is to investigate if a salt-reduced diet leads to an increased reward response when exposed to lower salt concentrations in food.

ANCA-associated Vasculitis and the Metabolic Syndrom

This study concerns a research that is aimed to investigate the prevalence of the metabolic syndrome in a group of patients known with ANCA-associated vaculitis. Hereby we will compare the presence of the metabolic syndrome between an ANCA-…

The AIM-to-OBserve study:
Adipokines and Inflammatory Markers in childhood OBesity

a) To investigate the differences in adipokines and inflammatory markers between obese and normal weight children; b) to study these differences over age, and c) to correlate adipokine/inflammatory marker profiles to clinical parameters for obesity…

Relative aerobic load and energy cost of balance control in elderly people walking with a unilateral lower limb prosthesis

The objective of this study is twofold. The first objective is to investigate the relative aerobic load during walking of people with a lower limb prosthesis. The second objective is to investigate the influence of balance control as a possible…

Multi-locus approach in pharmacogenetics. Application in the cholesterol lowering and anti-inflammatory pathways of statins

The aim of this project is to study SNPs in genes involved in the cholesterol lowering pathway and in the anti-inflammatory pathway of statins to explain differences in the protective effect of statins against myocardial infarction (MI). A second…

Autonomic function in Alzheimer: assessment using tilt-table testing

The primary objective is to determine if there is a difference in autonomic function between patients with Alzheimer*s disease (MCI and AD) and a matched control group. The secondary objectives will be explorative and aimed to investigate…

The vasoactive role of TRPV1, TRPA1 and TRPM3 in human dermal arteries

In this study the primary objective is to investigate whether activation of TRPV1, TRPA1 and TRPM3 by selective channel agonists induces vasodilation in human dermal arteries. If the primary objective is achieved, the secondary objective is to…

Long-term follow-up of the offspring born to mothers with a solid organ transplant.

The primary aim of the study is to assess the overall health of offspring born to a mother with solid organ transplantation, and to identify possible pre- and perinatal risks for diseases later in life. In addition, we would like to collect and…