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Rare Facial Clefts: Physical and Psychological Outcome and it's Implications, addendum: "Fysical features of patients with proven genetic mutation (EfnB1) and clinical diagnosis of Craniofrontonasal Dysplasia"

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Long-term stability and survival rates of a novel Oticon Medical bone conduction device implant

The overall aim of the study is to investigate the Ponto wide implant considering; initial implant stability, stability over time, skin reaction and long term success when loaded at 3 weeks post surgery. Patients* quality of life improvements…

Platelet function in minimal extracorporeal circulation versus conventional extracorporeal circulation in coronary artery bypass grafting

This study evaluates if there is a difference in platelet function during and following the use of minimal ECC compared with conventional ECC in coronary artery bypass grafting (CABG) analysed with tromboelastography en multiple electrode aggrometry…

In vitro maturation of human oocytes with subsequent IVF or ICSI . An observational study with follow up of the children.

The objective of this observational study is the safe introduction of clinical applied IVM in The Netherlands. During this study, the number and quality of the oocytes and embryos will be studied as well as pregnancy development. Emphasis will be on…

Maternal psychological Outcome after Multifetal pregnancy reduction

The primary objectives of this study are 1) to assess the factors and considerations that play a role in the decision-making process of either multifetal pregnancy reduction or maintaining a multifetal pregnancy, and 2) to assess the emotional…

Robot-assisted versus open extended lateral pancreaticojejunostomy for the treatment of symptomatic chronic pancreatitis (PANACOTTA): a multicenter patient- and assessor-blinded randomized trial

To assess the post-operative quality of recovery after robot-assisted as compared to open extended lateral pancreaticojejunostomy.

The CRYSTAL study: CMR of intraventricular flow analysis and genetic phenotyping in Hypertrophic Cardiomyopathy (HCM): a roadmap for surgical myectomy

The primary objective of this study is to assess wall shear stress in the left ventricle outflow tract using 4D flow CMR in healthy controls, asymptomatic HCM and before and after surgical myectomy in patients with HOCM,

The vasoactive role of TRPV1, TRPA1 and TRPM3 in human dermal arteries

In this study the primary objective is to investigate whether activation of TRPV1, TRPA1 and TRPM3 by selective channel agonists induces vasodilation in human dermal arteries. If the primary objective is achieved, the secondary objective is to…