50 results
Primary Objectives: To prospectively investigate the changes in cardiac parameters (echocardiography, NT-pro-BNP) and uteroplacental flow (pulsatility index, diastolic notching) during/after pregnancy in women with CHD and compare these changes with…
Speckle Tracking Imaging is a relatively new echocardiographic technique to quantify the left ventrikular twist and untwisting movement. Several populations like healthy adults and patients with hypertension, myocardial infarction or valvular…
1. To compare velocity encoded MRI and tissue Doppler echocardiography in the assessment of cardiac dyssynchrony2.To define the presence and degree of RV mechanical dyssynchrony in patients with corrected tetralogy of Fallot with RV dysfunction…
We set out to evaluate the genetic basis of dyslipidemia and cardiovascular disease.
Our objective is to measure systemic glycocalyx volume in patients with premature atherosclerotic disease before the age of 40 years and to compare this with a age and sex matched healthy control group.
1. The application of 4D flow MR imaging to analyse blood flow patterns (flow angle, flow asymmetry), regional vessel wall parameters (regional wall shear stress, vessel wall thickness) and pulsed-wave velocity in neoaortic root, carotid artery and…
Primary Objective(s): - To determine the relation between CPET and pulmonary and muscular performance in patients with Tetralogy of Fallot.- To study the effect of previous lateral thoracotomy on pulmonary function and exercise.Secondary Objective(s…
The primary objective of this study is to evaluate in subjects with LQT3:- The effect of oral eleclazine on mean daytime QTcF interval (in msec) after 24 weeks of treatment with eleclazine (based on standard 12-lead electrocardiogram [ECG] data)The…
Using epigenetic, transcriptional, metabolomic and proteomic approaches in cardiac and skeletal muscle tissue, we want to reveal distinct biological pathways affected in ACM, DCM and PLN r14del cardiomyopathy.
The aim is to obtain sufficient data about aortic hemodynamics and motion in MFS patients in different disease stages (e.g. native aorta, after conventional surgery and after PEARS procedure) and while receiving different medical treatments, to…
Main objectiveTo identify and describe the electrophysiological substrate and triggers in patients with (an increased risk of) VTAs using ECGI, in order to improve understanding of arrhythmic mechanisms and use these for arrhythmia risk…
In different stages of HCM, to measure the: - Myocardial perfusion- Myocardial function- Volume parameters of the heart- Fibrosis- Function of the small vessels (endothelial (dys)function)- Diastolic function and strain of the heart
Primary objectives: The first aim is to examine the role of microtubule network in electrical conduction, protein localization and function in induced cardiomyocytes from pediatric BrS patients, life threatening ventricular arrhythmia patients and…
The aim is to investigate the value of novel MRI parameters for aortic hemodynamics and aortic motion and pressure waveforms in MFS patients as potential new biomarkers for guiding surgical and medical treatment of MFS, by analysing these parameters…
To identify arrhythmogenic electromechanical risk profiles in LQTS patients; in baseline conditions and during provocation; the recognition of risk profiles will improve risk stratification for sudden cardiac death.
Evaluate the effect of the menstrual cycle on QTc among females with LQT1 or LQT2 and to put our previous findings in a broader perspective by including controls groups and older females.
The main objective of this study is to obtain valuable biomarkers that are useful in the prediction of the presence of (subtypes of PH) and/or treatment responses. Nucleic acid expression patterns will be determined in plasma and peripheral blood.…
Primary Objective: To investigate motor developmental outcome at school age of children with CHD compared to typically developing peers.Secondary Objective(s): - To investigate neurodevelopmental outcom eat school age on several developmental…
to quantify atrial electropathology of the endocardium in adult patients with CHD and to correlate clinical characteristics, atrial volume, electropathology, atrial ectopy and features of pre- and post-procedural atrial fibrillation.
The primary objective is to determine whether iRVF patterns and renal damage/function are different in patients with a Fontan circulation compared to age and sex-matched healthy controls.The secondary objectives are to- Identify the prevalence of…